CAS · 612548-45-5
Product Overview
Perindopril arginine is a high-purity a-api supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | White or almost white powder |
|---|---|
| Identification (IR) | Infrared absorption spectrum of sample should conform to that of standard |
| Identification (HPLC) | The retention time of major peak from sample solution corresponds to that from standard solution, as obtained in the assay test |
| Water | 5% max |
| Sulfated ash | 0.1% max |
| Impurity A (TLC) | 0.25% max |
| Stereochemical purity - Impurity I | 0.1% max |
| Stereochemical purity - Unspecified impurities | 0.1% max |
| Related substances - Impurity B | 0.3% max |
| Related substances - Impurity E | 0.4% max |
| Related substances - Impurity F | 0.2% max |
| Related substances - Unspecified impurities | 0.1% max |
| Total impurities | 1% max |
| Residual solvents - Ethanol | 5000 ppm max |
| Residual solvents - Ethyl acetate | 5000 ppm max |
| Residual solvents - Dichloromethane | 600 ppm max |
| Assay (HPLC) | 98.0% ~ 102.0% (On the anhydrous and solvent-free basis) |
Applications
Perindopril arginine is an active pharmaceutical ingredient (API) widely used in cardiovascular therapy and pharmaceutical research. It functions as an angiotensin-converting enzyme (ACE) inhibitor, helping to manage hypertension, heart failure, and reduce the risk of cardiovascular events. In clinical and pharmaceutical applications, it is incorporated into tablets and combination therapies for long-term blood pressure control and cardioprotection. In drug development and formulation research, perindopril arginine is used to optimize solubility, bioavailability, and stability in oral dosage forms. It also serves as a reference compound in pharmacokinetic studies, analytical method development, and quality control testing for ACE inhibitor-based therapies.
Benefits
The benefits of perindopril arginine arise from its potent ACE inhibition, good oral bioavailability, and stable arginine salt form. It effectively reduces angiotensin II levels, leading to vasodilation, improved cardiac output, and blood pressure regulation. The arginine salt enhances solubility and chemical stability, allowing for more consistent dosing and extended shelf life of pharmaceutical formulations. Its predictable pharmacokinetics support once-daily dosing regimens, improving patient compliance. Additionally, perindopril arginine demonstrates compatibility with other antihypertensive agents, enabling combination therapies for broader cardiovascular protection. Its well-characterized profile ensures reproducibility and reliability in pharmaceutical research and development.
Conclusion
Perindopril arginine is a valuable cardiovascular agent and pharmaceutical intermediate with applications in hypertension and heart failure therapy. Its potent ACE inhibition, stable salt form, and high bioavailability make it an essential compound in modern cardiovascular medicine. By supporting effective blood pressure control, improved cardiac function, and reliable pharmaceutical formulation, perindopril arginine continues to play a critical role in therapeutic development and cardiovascular research.
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