CAS · 222978-03-2
Product Overview
4-Cyano-3-fluorobenzyl bromide is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | Off-white solid |
|---|---|
| Purity | 98% min |
| Water | 0.5% max |
Applications
4-Cyano-3-fluorobenzyl bromide (CAS 222978-03-2) is a versatile halogenated aromatic compound widely used as an intermediate in pharmaceutical, agrochemical, and fine chemical synthesis. Its bromide functionality allows for nucleophilic substitution reactions, making it an essential building block for the preparation of heterocycles, benzyl derivatives, and bioactive molecules. In medicinal chemistry, it is employed in the synthesis of enzyme inhibitors, receptor modulators, and other drug candidates, particularly in the design of fluorinated compounds which often exhibit enhanced metabolic stability and biological activity. Additionally, it is used in the synthesis of specialty chemicals, fluorinated materials, and as a reactive substrate in cross-coupling reactions for advanced organic synthesis.
Benefits
The benefits of 4-Cyano-3-fluorobenzyl bromide stem from its combination of reactive and electron-withdrawing groups. The bromide moiety enables efficient nucleophilic substitution, while the cyano and fluorine substituents enhance chemical stability, electron density control, and molecular recognition properties in subsequent derivatives. Its reactivity allows for selective functionalization, enabling the production of complex molecules with high yield and minimal side reactions. The compound is also compatible with common organic solvents and standard synthetic conditions, making it convenient for laboratory-scale and industrial-scale chemical synthesis. The presence of fluorine provides additional advantages in medicinal chemistry, such as improved lipophilicity, metabolic stability, and binding affinity in target molecules.
Conclusion
4-Cyano-3-fluorobenzyl bromide is a valuable intermediate in pharmaceutical, agrochemical, and fine chemical synthesis. Its reactive bromide group and electron-withdrawing substituents enable selective functionalization and efficient construction of complex, bioactive, and fluorinated molecules. By supporting advanced organic synthesis and medicinal chemistry applications, it remains an important tool for developing high-performance chemicals and drug candidates.
Previous
1-(5-bromo-2-methylphenyl)ethanone丨CAS 90326-54-8
Next