CAS · 363-72-4
Product Overview
Pentafluorobenzene is a high-purity fluorine supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance: | Colourless transparent liquid |
|---|---|
| Purity (GC): | 99.0% min |
| Boiling Point: | 84.5-85.5℃ |
| Density: | 1.51-1.54 g/cm³ |
Applications
1. Synthetic Intermediate in Fluoroarene Chemistry
Acts as a building block for synthesizing more complex perfluoroaryl compounds via nucleophilic aromatic substitution (SNAr), especially with amines, thiols, or alkoxides.
Used in the preparation of functionalized fluorobenzenes and ligands for catalysis.
2. Ligand Design in Organometallic Chemistry
Employed as a π-ligand or substituent in transition metal complexes to modulate electronic properties due to its strong electron-withdrawing fluorine atoms.
Useful in designing catalysts with fine-tuned reactivity for cross-coupling reactions or C–H activation.
3. Pharmaceutical and Agrochemical Research
Pentafluorobenzene丨CAS 363-72-4 provides a fluorinated aromatic scaffold in medicinal chemistry for drug candidates requiring enhanced metabolic stability or lipophilicity.
Investigated for inclusion in bioactive molecules to modulate binding affinity, selectivity, and membrane permeability.
4. Spectroscopy and Analytical Chemistry
Due to the presence of fluorine atoms, pentafluorobenzene is useful in NMR spectroscopy as a chemical shift reference or probe in ¹⁹F NMR studies.
Also serves as a solvent or co-solvent in fluorine-rich reaction media for analytical and research use.
5. Materials Science
Incorporated in the synthesis of fluorinated polymers and organic electronic materials, including OLEDs and liquid crystals, where hydrophobicity and thermal stability are critical.
The presence of multiple C–F bonds imparts chemical resistance and dielectric properties, useful in specialty coatings and insulators.
Benefits
1. High Reactivity Toward Nucleophiles
The electron-deficient ring enables easy substitution, making it a versatile precursor for further functionalization.
2. Thermal and Chemical Stability
Fluorinated compounds like pentafluorobenzene are typically resistant to oxidation, hydrolysis, and UV degradation.
3. Unique Electronic Properties
Ideal for tuning electron density in drug candidates or catalyst systems.
4. NMR Sensitivity
Excellent ¹⁹F NMR visibility, allowing clear tracking in fluorinated compound synthesis.
Conclusion
A concise summary and suitability assessment for this product is available on request. Contact our team to discuss whether it fits your process and quality requirements.