CAS · 371-40-4
Product Overview
4-Fluoroaniline is a high-purity fluorine supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | Colorless to reddish brown and transparent liquid, slightly soluble in water |
|---|---|
| Content | 99.5% min |
| Water | 0.2% max |
| Impurity | 0.2% max |
Applications
1. Pharmaceutical Intermediates
● Used in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates.
● Serves as a building block for aniline-based drug molecules, particularly in analgesics, anti-inflammatory drugs, and antidepressants.
2. Agrochemical Intermediates
● 4-Fluoroaniline丨CAS 371-40-4 Acts as a precursor in the synthesis of herbicides, fungicides, and insecticides.
● Its functionalized aromatic structure allows for tailored agrochemical properties.
3. Dye and Pigment Manufacturing
● Used in the production of azo dyes, fluorinated colorants, and specialty pigments.
● Enhances colorfastness, UV resistance, and chemical stability of the resulting dyes.
4. Specialty Polymers and Resins
● Employed in the synthesis of fluorinated monomers for engineering plastics, coatings, and high-performance materials.
● Fluorinated moieties improve chemical resistance and thermal stability.
5. Organic Synthesis and Research
● Commonly used in structure–activity relationship (SAR) studies to investigate the effect of fluorine substitution on aromatic amines.
● Functions as a nucleophilic reagent or substituted aniline in the formation of heterocycles, Schiff bases, and azo compounds.
Benefits
✅ Fluorine-Enhanced Properties
● The fluorine atom modulates electronic properties, leading to increased metabolic stability and bioavailability in drug and agrochemical design.
✅ Reactivity for Derivatization
● The amino group provides a versatile handle for nucleophilic substitution, amide formation, and diazotization.
✅ Useful in Material Science
● Enhances thermal and chemical resistance in high-performance polymers and coatings.
✅ Synthetic Versatility
● Offers a functionalized aromatic ring, enabling downstream synthesis of complex molecules.
Conclusion
4-Fluoroaniline丨CAS 371-40-4 is a valuable chemical intermediate used widely in the pharmaceutical, agrochemical, and dye industries, as well as in research and advanced material development. Its dual functionality-an amino group and a para-fluorine substituent-offers a powerful combination for synthetic chemists looking to tailor molecular properties in various applications.
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