CAS · 14698-29-4
Product Overview
Oxolinic acid is a high-purity bactericides supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | White or almost white crystal or crystalline powder; smelless |
|---|---|
| Identification A | Dissolve 1 mg of sample with 2 ml of sulfuric acid, add three drops of chromotropic acid solution, heat in water-bath at 40℃ for 10 minutes; purple colour is obtained |
| Identification B | UV absorption Max. at 258, 266, 326 and 340 nm |
| Identification C | IR spectra is consistent with CRS |
| Chlorides | ≤ 0.012% |
| Heavy metals | ≤ 10 ppm |
| Loss on drying | ≤ 0.2% |
| Sulphated ash | ≤ 0.1% |
| Assay | 98% – 102% |
Applications
Oxolinic acid is primarily used as a broad-spectrum antibacterial agent in veterinary medicine. It is applied in the treatment and prevention of bacterial infections in fish, poultry, and livestock caused by Gram-negative and Gram-positive pathogens. The compound is commonly formulated in medicated feed or oral solutions to control diseases such as enteric infections, septicaemia, and respiratory disorders in aquaculture and livestock industries. In addition to therapeutic applications, oxolinic acid is used in research to study bacterial DNA gyrase inhibition, antimicrobial resistance mechanisms, and pharmacokinetics of quinolone-based antibacterial agents. Its structure also serves as a reference molecule in the development and optimization of next-generation quinolone antibiotics.
Benefits
Oxolinic acid offers several advantages due to its potent antibacterial activity and targeted mechanism of action. As a quinolone derivative, it inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication and transcription in susceptible bacteria. This mode of action provides effective treatment of infections, particularly in aquaculture and veterinary applications where bacterial resistance to other antibiotics may be present. The compound is stable, easily formulated into feed or oral solutions, and demonstrates good bioavailability, allowing for efficient therapeutic administration. Its broad-spectrum activity and predictable pharmacokinetics make it a reliable option for managing bacterial infections in diverse animal species.
Conclusion
Oxolinic acid is a valuable quinolone antibacterial agent widely used in veterinary medicine and aquaculture. Its applications in controlling bacterial infections, combined with benefits such as potent activity, stability, and predictable pharmacokinetics, make it an essential tool for maintaining animal health and productivity. The compound also plays an important role in research on antibacterial mechanisms and the development of new quinolone antibiotics.
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