CAS · 287714-35-6
Product Overview
methyl 2-chloropyrimidine-5-carboxylate is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | Off-white or light yellow solid powder |
|---|---|
| Purity | 98% min |
| Loss on drying | 0.5% max |
Applications
Methyl 2-chloropyrimidine-5-carboxylate (CAS 287714-35-6) is a heteroaromatic intermediate widely used in pharmaceutical and agrochemical synthesis. Its pyrimidine scaffold makes it a core building block in the preparation of bioactive molecules, including kinase inhibitors, antivirals, and antibacterial compounds. The compound's chloro substituent serves as a reactive site for nucleophilic substitution, cross-coupling, and heterocyclic functionalization, enabling the synthesis of structurally diverse derivatives. In agrochemistry, it is employed in the design of herbicides and fungicides, where the pyrimidine core contributes to selective biological activity. It is also utilized in fine chemical and material science research for the preparation of functionalized heteroaromatics with tailored electronic properties.
Benefits
The benefits of methyl 2-chloropyrimidine-5-carboxylate come from its dual functional groups and heteroaromatic framework. The ester moiety provides a handle for hydrolysis, amidation, or transesterification, while the chloro substituent offers versatility for selective substitutions and cross-coupling reactions. This combination enables efficient multi-step synthetic strategies from a single intermediate. Its pyrimidine core, common in nucleobase analogs and enzyme-binding motifs, increases its relevance in drug discovery and agrochemical development. The compound is also relatively stable and easy to handle, allowing reproducible incorporation into complex synthetic pathways.
Conclusion
In summary, methyl 2-chloropyrimidine-5-carboxylate is a valuable heterocyclic intermediate applied in pharmaceuticals, agrochemicals, and fine chemical research. Its applications include the synthesis of kinase inhibitors, antimicrobial agents, herbicides, and functional heteroaromatics, while its benefits lie in versatile reactivity, dual functional groups, and biological relevance of the pyrimidine scaffold. With these attributes, it serves as an essential building block for developing innovative bioactive and functional molecules.
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