CAS · 89226-75-5
Product Overview
Manidipine hydrochloride is a high-purity a-api supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Grade | JP |
|---|---|
| Description | White to light yellow crystalline or crystalline powder |
| Assay | 98.0% ~ 101.0% |
| Melting Point | About 207 °C with decomposition |
| Loss on Drying | 1.5% max |
| Residue on Ignition | 0.2% max |
| Heavy metals | 0.001% max |
| Arsenic | 0.0001% max |
| Individual impurity | 0.2% max |
| Total impurity | 0.7% max |
| Identification | The infrared absorption is same as Confirm Max. absorption is in the wavelength 228 nm Responds to the Qualitative Tests <1.09> for chlorides |
Applications
Manidipine hydrochloride is primarily used as a pharmaceutical agent for the treatment of hypertension (high blood pressure). It belongs to the class of calcium channel blockers, specifically dihydropyridine derivatives, and is prescribed to relax and widen blood vessels, improving blood flow and reducing blood pressure. It is also studied for potential benefits in managing cardiovascular diseases, such as angina pectoris, and for protecting kidney function in hypertensive patients.
Benefits
Manidipine hydrochloride offers effective blood pressure reduction with a relatively favorable side-effect profile compared to some other calcium channel blockers. Its long-acting nature allows for once-daily dosing, improving patient compliance. Additionally, it demonstrates vasoselectivity, preferentially targeting vascular smooth muscle, which helps minimize adverse cardiac effects. The drug may also provide renal protection by improving blood flow to the kidneys and reducing proteinuria.
Conclusion
Manidipine hydrochloride is an important antihypertensive medication that combines efficacy with patient-friendly dosing and safety. Its use contributes significantly to managing hypertension and related cardiovascular risks, enhancing patient quality of life and reducing complications associated with high blood pressure.
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