CAS · 125562-30-3
Product Overview
m-PEG9-bromide is a high-purity polyethylene-glycol supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | Yellow liquid |
|---|---|
| Purity | 97% min |
| Water content | 1% max |
Applications
m-PEG9-bromide is widely used as a key intermediate in organic synthesis, bioconjugation, and polymer chemistry. Its structure-a monomethoxy polyethylene glycol (PEG) chain with a terminal bromide-makes it ideal for introducing PEG spacers into small molecules, peptides, proteins, and other biomolecules. It is commonly applied in the synthesis of PEGylated drugs, where the PEG chain improves solubility, stability, and pharmacokinetics. Additionally, it is used in preparing functionalized polymers, surfactants, and dendrimers, and serves as a building block in the design of drug delivery systems, antibody-drug conjugates (ADCs), and other biologically relevant constructs that require water solubility and biocompatibility.
Benefits
The main benefits of m-PEG9-bromide stem from its reactive bromide group and flexible PEG9 chain. The bromide allows for efficient nucleophilic substitution reactions, enabling selective and reliable functionalization of molecules. The PEG9 chain enhances water solubility, reduces aggregation, and improves circulation time for PEGylated therapeutics, which is critical in pharmaceutical development. Its chemical stability and reproducible performance under typical storage and reaction conditions make it a reliable intermediate. Overall, it allows chemists to design molecules with enhanced pharmacokinetic profiles, improved solubility, and tailored functional properties.
Conclusion
m-PEG9-bromide is a versatile and valuable intermediate in modern chemical synthesis and bioconjugation. Its combination of a reactive bromide and a PEG9 chain enables selective functionalization and PEGylation of molecules, enhancing solubility, stability, and pharmacokinetics. By providing a reliable platform for constructing PEGylated drugs, polymers, and advanced biomolecules, it plays a critical role in pharmaceutical research, material science, and drug delivery development.
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