CAS · 1453-82-3
Product Overview
Isonicotinamide is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance: | Off-white to beige-yellow powder |
|---|---|
| Assay (on dry basis): | 98.5% min. |
| MP: | 155°C to 157°C |
| Loss on drying: | 0.5% max. |
| Heavy metals: | 0.002% max. |
| Residue on ignition: | 0.1% max. |
Applications
1. Pharmaceutical Industry
Key Intermediate in Drug Synthesis: Isonicotinamide is an important building block in the manufacture of drugs such as isoniazid, a frontline antitubercular agent.
Precursor to Bioactive Compounds: Used in the synthesis of various compounds exhibiting antimicrobial, anticancer, and anti-inflammatory activities.
Coordination Complexes: Forms complexes with metals that have potential therapeutic applications.
2. Coordination Chemistry and Material Science
Ligand in Metal Complexes: Acts as a bidentate ligand coordinating through the nitrogen of the pyridine ring and the oxygen of the amide group.
Catalysis and Material Design: Used in the development of catalysts and novel materials due to its ability to form stable complexes.
3. Organic Synthesis
Utilized as a building block or intermediate in the synthesis of heterocyclic compounds and other nitrogen-containing molecules.
Employed in the development of novel synthetic routes due to its reactivity and functional groups.
Benefits
Versatile Reactivity: The amide and pyridine functionalities enable diverse chemical transformations.
Pharmaceutical Importance: Critical intermediate for drugs with significant global health impact.
Stable and Easy to Handle: Solid form and good thermal stability facilitate industrial processing.
Facilitates Coordination Chemistry: Useful for creating complexes with potential biological and catalytic properties.
Conclusion
Isonicotinamide (CAS 1453-82-3) is a valuable chemical intermediate widely used in pharmaceutical manufacturing, especially in the synthesis of antitubercular agents. Its role as a ligand in coordination chemistry and as a versatile building block in organic synthesis underlines its importance in both medicinal chemistry and materials science. The compound's stability and multifunctionality make it a staple in chemical research and industrial applications.
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