CAS · 50586-80-6
Product Overview
m-PEG3-Tos is a high-purity polyethylene-glycol supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | White solid |
|---|---|
| Purity (by HPLC) | 97% min |
| Homologue impurity | 0.5% max |
Applications
m-PEG3-Tos is a functionalized polyethylene glycol derivative commonly used in organic synthesis, bioconjugation, and materials science. The molecule consists of a short PEG3 chain terminated with a tosyl (p-toluenesulfonyl) group, which makes it an effective leaving group for nucleophilic substitution reactions. It is frequently applied as a PEGylation reagent to attach PEG chains to small molecules, peptides, proteins, or other functionalized substrates, enhancing solubility, stability, and pharmacokinetic properties. In polymer chemistry, m-PEG3-Tos serves as a precursor for synthesizing PEG-functionalized polymers, surfactants, and amphiphilic materials. It is also utilized in the preparation of linkers and spacers in bioconjugates, drug delivery systems, and chemical probes, where precise control over chain length and attachment is required. The compound's tosyl group allows selective reactions under mild conditions, facilitating the introduction of PEG moieties without affecting sensitive functional groups.
Benefits
m-PEG3-Tos provides several advantages in chemical synthesis and bioconjugation. The short PEG3 chain imparts water solubility, flexibility, and reduced steric hindrance, which is important for maintaining biological activity after conjugation. The tosyl leaving group enables efficient and predictable nucleophilic substitution, allowing for controlled PEGylation of alcohols, amines, thiols, and other nucleophiles. This facilitates the synthesis of functionalized molecules and linkers with high yield and reproducibility. The compound is stable under standard laboratory conditions and is compatible with a range of solvents and reaction conditions, making it versatile in multi-step syntheses. By enabling the introduction of PEG chains, m-PEG3-Tos helps improve solubility, reduce aggregation, and enhance the pharmacokinetic and pharmacodynamic properties of therapeutic molecules, while also serving as a modular component in materials and polymer science applications.
Conclusion
m-PEG3-Tos is a versatile PEG derivative used in organic synthesis, bioconjugation, and polymer chemistry. Its short PEG3 chain provides solubility and flexibility, while the tosyl group acts as an efficient leaving group for nucleophilic substitution reactions. The compound enables controlled PEGylation, linker formation, and functionalization of small molecules, peptides, proteins, and polymers, improving solubility, stability, and performance. By combining chemical reactivity with practical handling and predictable outcomes, m-PEG3-Tos supports efficient and reproducible synthesis in pharmaceutical, biotechnological, and materials science applications.
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