CAS · 86087-23-2
Product Overview
(S)-(+)-3-Hydroxytetrahydrofuran is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | Colorless to pale yellow oil liquid |
|---|---|
| Purity | 98% min |
| Water | 1.0% max |
| Excess enantiomer | 98% min |
Applications
(S)-(+)-3-Hydroxytetrahydrofuran (CAS 86087-23-2) is a chiral oxygen-containing heterocycle widely used as an intermediate in pharmaceutical, agrochemical, and fine chemical synthesis. Its enantiomerically pure form makes it particularly valuable in the preparation of chiral drug candidates, active pharmaceutical ingredients (APIs), and stereochemically defined intermediates. The hydroxyl group enables further functionalization through esterification, etherification, oxidation, or substitution reactions, allowing incorporation into more complex molecular frameworks. It is also used in the synthesis of nucleoside analogues, chiral auxiliaries, and ligands, as well as in structure–activity relationship studies where controlled stereochemistry is essential. In research settings, it serves as a model compound for studying chiral heterocycles and stereoselective transformations.
Benefits
The benefits of (S)-(+)-3-hydroxytetrahydrofuran arise from its high enantiomeric purity, structural simplicity, and versatile reactivity. The defined (S)-configuration enables precise control of stereochemistry in downstream synthesis, which is critical for achieving desired biological activity and regulatory compliance in pharmaceuticals. The tetrahydrofuran ring provides chemical stability and favorable solubility in common organic solvents, while the hydroxyl functionality offers multiple pathways for selective derivatization. Its compatibility with standard synthetic conditions allows efficient, reproducible reactions and scalable processes. These properties make it a reliable and flexible chiral building block for complex molecule construction.
Conclusion
(S)-(+)-3-Hydroxytetrahydrofuran is a valuable chiral intermediate used extensively in pharmaceutical and fine chemical synthesis. Its enantiomeric purity, functional versatility, and stable heterocyclic structure support efficient stereoselective synthesis and molecular optimization. By enabling precise control over chirality and reactivity, it plays an important role in modern medicinal chemistry and advanced organic synthesis.
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