CAS · 66108-95-0
Product Overview
Iohexol is a high-purity pharmaceutical-excipients supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Grade | USP |
|---|---|
| Appearance | White or almost-white, odorless and hygroscopic powder |
| Identification | Conforms |
| Assay (on anhydrous) | 98%-102% |
| Ionic Compounds | 0.01% max |
| Free Iodide | 0.001% max |
| Related Substances - O-Alkylated Compounds | 0.6% max |
| Related Substances - Any Individual Impurity | 0.1% max |
| Total Impurities (Excluding O-Alkylated Compounds) | 0.3% max |
| 2-Methoxyethanol | 20 ppm max |
| 3-Chloropropane-1,2-diol | 0.00025% max |
| Free Aromatic Amine | 0.05% max |
| Color of Solution | The absorbances of the sample solution at 400 nm, 420 nm, and 450 nm should be not more than 0.180, 0.030, and 0.015, respectively. |
| Water | 4.0% max |
| Bacterial Endotoxin | 0.7 EU/g max |
| Microbiological Test - Aerobic Bacteria | 1000 cfu/g max |
| Microbiological Test - Mold and Yeast | 100 cfu/g max |
| Microbiological Test - E. coli | Negative/g |
Applications
Medical Imaging (Contrast Agent)
Iohexol丨66108-95-0 is widely used as a non-ionic iodinated contrast agent in diagnostic imaging procedures such as computed tomography (CT) scans, angiography, urography, and myelography. It enhances the visibility of blood vessels, organs, and tissues by increasing X-ray absorption, allowing for clearer and more detailed imaging.
Cardiovascular Diagnosis
In angiography, iohexol helps visualize blood vessels, aiding in the diagnosis of cardiovascular diseases such as blockages, aneurysms, and arterial abnormalities. It is particularly valuable in coronary angiography for assessing heart conditions.
Neurological Imaging
For myelography, iohexol is injected into the spinal canal to evaluate conditions affecting the spinal cord and nerve roots, such as herniated discs and spinal tumors. It provides clear imaging of the cerebrospinal fluid pathways.
Renal and Urinary Tract Diagnosis
Iohexol is used in intravenous urography and pyelography to assess kidney function, detect urinary tract obstructions, and diagnose structural abnormalities of the urinary system.
Guided Medical Procedures
It is also used in fluoroscopy-guided interventions, including catheter placements and endoscopic retrograde cholangiopancreatography (ERCP) for evaluating the bile ducts and pancreas.
Glomerular Filtration Rate (GFR) Measurement
Iohexol is used in nephrology to measure kidney function by determining the glomerular filtration rate (GFR). It provides a reliable alternative to traditional creatinine clearance tests.
Benefits
High Imaging Clarity
As a non-ionic contrast agent, Iohexol丨66108-95-0 provides high-quality imaging with minimal background interference, improving diagnostic accuracy.
Low Toxicity and High Safety Profile
Iohexol is preferred due to its low osmolality and reduced risk of adverse reactions compared to older ionic contrast media. It is well tolerated by most patients, including those with renal impairment when used appropriately.
Wide Range of Diagnostic Applications
Its versatility in various imaging techniques, including CT, angiography, and urography, makes it a critical tool in medical diagnostics.
Rapid Clearance from the Body
Iohexol is primarily excreted through the kidneys, with a short half-life, reducing the risk of long-term accumulation in the body.
Improved Patient Comfort
Due to its lower viscosity and lower likelihood of causing pain or discomfort during injection, iohexol enhances patient experience during imaging procedures.
Conclusion
Iohexol丨66108-95-0 is an essential contrast agent used in medical imaging to enhance diagnostic accuracy in various fields, including neurology, cardiology, nephrology, and interventional radiology. Its safety, effectiveness, and broad diagnostic applications make it a preferred choice for healthcare professionals worldwide.
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