CAS · 92339-11-2
Product Overview
Iodixanol is a high-purity a-api supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | White or almost white powder |
|---|---|
| Assay | 98.5%–101.0% (on anhydrous and solvent-free basis) |
| Identification | IR: Spectrum corresponds to CRS HPLC: 3 principal peaks match system suitability solution 1 |
| Appearance of solution | Clear and not more intensely coloured than reference solution Y7 |
| Related Substances | Impurity A: 0.10% max Impurity B: 0.10% max Impurity C: 0.4% max Impurity F: 0.10% max Impurity G: 0.10% max Impurity H: 0.6% max Overalkylated impurities: 1.0% max Any unspecified impurity: 0.10% max Total impurities: 1.5% max Impurity: 0.3% max |
| Residual Solvents | Methanol: 50 ppm max Ethanol: 50 ppm max |
| Free Aromatic Amine | 250 ppm max |
| Free Iodine | Toluene layer shows no red or pink colour |
| Iodide | 10 ppm max |
| Ionic Compounds | 0.02% max (as sodium chloride) |
| Water | 4.0% max |
Applications
1. Radiographic Contrast Agent
Iodixanol is used in a variety of X-ray–based imaging techniques to improve contrast between different tissues:
● Computed Tomography (CT): Enhances visibility of organs and vasculature.
● Angiography: Allows detailed imaging of arteries and veins, including cerebral, coronary, and peripheral vessels.
● Urography: Assists in imaging of kidneys, ureters, and bladder.
● Cardiac Imaging: Commonly used in coronary angiography to identify blockages or abnormalities in heart vessels.
● Myelography: Occasionally used for spinal cord and nerve root imaging.
● Venography and Arthrography: Provides detailed joint or vein visualization.
2. Density Gradient Medium in Cell Separation
Iodixanol丨CAS 92339-11-2 is also utilized in life sciences as a density gradient medium, especially for:
● Organelle Isolation: Efficiently separates cellular components such as mitochondria, nuclei, or endosomes based on density.
● Virus Purification: Particularly effective in ultracentrifugation protocols for separating adenoviruses, lentiviruses, and AAVs.
● Exosome and Lipoprotein Research: Useful for high-resolution separation of exosomes, lipoproteins (e.g., LDL, HDL), and extracellular vesicles.
This form of Iodixanol (often under the name OptiPrep) is used extensively in cell biology and virology labs.
3. Stem Cell and Protein Work
Iodixanol gradients are gentle and non-toxic, which helps preserve protein function, cell integrity, and viability, making it valuable in sensitive biological preparations.
Benefits
✅ Iso-osmolarity
● Iodixanol is iso-osmolar to plasma, reducing the risk of adverse physiological responses compared to hyperosmolar agents.
● Particularly safer for patients with renal impairment, diabetes, or cardiovascular conditions.
✅ Low Toxicity
● Low incidence of nephrotoxicity (contrast-induced nephropathy) compared to other iodinated agents.
● Lower risk of allergic or anaphylactoid reactions.
✅ High Image Quality
● Provides excellent contrast enhancement in vascular and soft tissue imaging, improving diagnostic accuracy.
✅ Biological Compatibility
● In laboratory use, iodixanol is non-ionic, non-toxic, and inert, making it ideal for live cell work, virus handling, and gradient centrifugation.
✅ Thermal and Chemical Stability
● Highly stable under standard storage and experimental conditions.
● Can be sterilized and stored for long periods without decomposition.
Conclusion
Iodixanol丨CAS 92339-11-2 is a dual-purpose compound with wide-ranging applications in both clinical radiology and biological research. Its iso-osmolar, nonionic profile makes it a preferred contrast agent for patients requiring diagnostic imaging with reduced risk, while its gentle, non-toxic properties make it indispensable in advanced cell separation, virology, and biomolecular research. Whether enhancing the clarity of a coronary angiogram or enabling the clean isolation of viruses and organelles, Iodixanol continues to be a critical tool in modern science and medicine.
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