CAS · 393-52-2
Product Overview
2-Fluorobenzoyl chloride is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | Colorless to light yellow transparent liquid or crystal |
|---|---|
| Purity (GC) | 99.0% min |
| Color (Pt-Co) | 50 max |
| 4-Fluorobenzoyl Chloride | 0.1% max |
| 3-Fluorobenzoyl Chloride | 0.2% max |
| Benzoyl Chloride | 0.1% max |
| 2-Fluorodichlorobenzyl | 0.1% max |
| 2-Fluorobenzotrichloride | 0.2% max |
| Any Individual Impurity (max) | 0.3% max |
Applications
2-Fluorobenzoyl chloride is an important acyl chloride used as a reactive intermediate in organic synthesis, pharmaceuticals, agrochemicals, and material sciences. It is widely applied in the preparation of aromatic ketones, amides, esters, and heterocyclic compounds, where its fluoro-substituted benzoyl moiety imparts enhanced chemical stability and bioactivity. In pharmaceutical research, it serves as a key building block for the synthesis of drugs and bioactive molecules, helping to introduce fluorine atoms that improve metabolic stability, binding affinity, and overall pharmacokinetic properties. In agrochemical applications, 2-fluorobenzoyl chloride is used to synthesize herbicides, insecticides, and fungicides with enhanced efficacy. Additionally, it is utilized in material science for producing specialty polymers, dyes, and functionalized surfaces where fluorine substitution enhances performance and durability.
Benefits
The primary benefits of 2-fluorobenzoyl chloride lie in its high reactivity, versatility, and ability to introduce fluorine into complex molecules. The presence of the fluorine atom provides electronic and steric effects that improve chemical selectivity and the biological properties of target compounds. Its acyl chloride functionality allows efficient formation of ketones, amides, and esters under mild conditions, enabling streamlined synthetic routes and reducing reaction times. For pharmaceutical and agrochemical synthesis, it contributes to higher product yields, improved stability, and enhanced efficacy. In materials chemistry, the fluorine-substituted aromatic structure supports improved thermal stability, chemical resistance, and performance of end products. Overall, its combination of reactivity and functional versatility makes it a valuable intermediate in research and industrial applications.
Conclusion
In conclusion, 2-fluorobenzoyl chloride is a highly versatile intermediate used in pharmaceuticals, agrochemicals, and material science. Its applications include the synthesis of aromatic ketones, amides, esters, heterocyclic compounds, and functionalized materials, while its benefits encompass high reactivity, fluorine-enhanced chemical and biological properties, improved yields, and process efficiency. With its broad utility and performance advantages, 2-fluorobenzoyl chloride remains an essential compound for chemical innovation and industrial development.
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