CAS · 1467-16-9
Product Overview
Imidazole hydrochloride is a high-purity biological-buffer supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance: | White or off-white crystals |
|---|---|
| Assay: | 97.0% min |
| Loss on drying: | 0.5% max |
Applications
1. Biochemical Buffering Agent
Imidazole hydrochloride丨CAS 1467-16-9 is commonly used as a buffering agent in protein purification, especially in nickel-affinity chromatography (His-tag purification). It helps maintain a stable pH and elutes histidine-tagged proteins by competing for binding sites on the metal ion column.
2. Pharmaceutical Intermediate
This compound serves as a synthetic intermediate in the production of antifungal agents, anti-inflammatory drugs, and other imidazole-based pharmaceuticals. Its enhanced solubility in water facilitates use in aqueous reaction systems.
3. Enzyme and Protein Studies
Imidazole derivatives are known to mimic histidine residues in enzyme active sites. Imidazole hydrochloride is employed in research to investigate enzyme mechanisms, catalysis, and protein-ligand interactions.
4. Chemical Synthesis and Catalysis
In organic synthesis, imidazole hydrochloride acts as a precursor or catalyst for creating imidazole-containing compounds. It is also involved in heterocyclic synthesis and peptide coupling reactions.
5. Coordination Chemistry
Due to its nitrogen-rich structure, imidazole hydrochloride is used in coordination chemistry to prepare metal complexes, which are studied for their catalytic, magnetic, or electronic properties.
Benefits
✅ Enhanced Water Solubility
Compared to free imidazole, the hydrochloride salt dissolves more readily in water, making it more practical in biological and aqueous chemical processes.
✅ Biocompatibility
Non-toxic at working concentrations, imidazole hydrochloride is suitable for biological assays, especially those involving proteins and enzymes.
✅ Versatile Usage
Its roles range from buffering and ligand preparation to drug precursor, offering broad utility in lab and industrial settings.
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Conclusion
A concise summary and suitability assessment for this product is available on request. Contact our team to discuss whether it fits your process and quality requirements.