CAS · 72509-76-3
Product Overview
Felodipine is a high-purity a-api supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Property | Specification |
|---|---|
| Grade | USP32 |
| Appearance | White to light yellow crystalline powder |
| Assay (on dry basis) | 98.0% ~ 101.0% |
| Identification | 1. The retention of the major peak of the Assay preparation corresponds to the Standard preparation |
| 2. The infrared absorption is same as reference | |
| Solubility | Practically insoluble in water, freely soluble in acetone, ethanol, methanol, and methylene chloride |
| Colour of solution | Should meet the requirements |
| Related substances | Other single impurity: 1.0% max |
| Total impurities: 1.5% max | |
| Loss on drying | 0.5% max |
| Residue on ignition | 0.1% max |
| Heavy metals | 0.002% max |
Applications
1. Hypertension (High Blood Pressure)
Felodipine丨CAS 72509-76-3 is commonly prescribed as an antihypertensive agent to manage high blood pressure, either as a monotherapy or in combination with other antihypertensive drugs. It helps:
● Relax blood vessels by blocking calcium from entering smooth muscle cells, which reduces blood vessel constriction and lowers blood pressure.
● Control long-term hypertension: It helps reduce the risk of complications such as stroke, heart attack, and kidney damage caused by sustained high blood pressure.
2. Angina Pectoris (Chest Pain)
Felodipine is also used to treat stable angina (chest pain due to coronary artery disease) by improving blood flow to the heart muscle. Its vasodilatory effects:
● Increase oxygen supply to the heart, reducing the occurrence of angina attacks.
● Relieve chest pain by reducing the work the heart must do to pump blood.
3. Management of Coronary Artery Disease
Felodipine may be prescribed as part of the treatment for coronary artery disease (CAD), as it helps improve coronary blood flow and reduce symptoms of ischemia (reduced blood flow to the heart muscle). This aids in preventing further complications in CAD patients.
Benefits
1. Effective Blood Pressure Control
Felodipine丨CAS 72509-76-3 offers potent and sustained blood pressure reduction, helping patients maintain long-term control over hypertension. Its once-daily dosing increases patient compliance.
● Long-acting formulation ensures consistent effects throughout the day.
● Improved quality of life: By controlling blood pressure, it reduces the risk of cardiovascular events like heart failure, stroke, or kidney failure.
2. Fewer Side Effects Compared to Other Calcium Channel Blockers
Felodipine is generally better tolerated than some other calcium channel blockers, especially non-dihydropyridines like verapamil or diltiazem, which have a stronger effect on the heart rate. Felodipine has:
● Minimal effects on heart rate: It primarily acts on the blood vessels, leading to less risk of bradycardia (slowed heart rate).
● Lower risk of peripheral edema: Though edema (swelling) can still occur, it is less common compared to other calcium channel blockers.
3. Improved Angina Control
Felodipine provides significant relief from angina symptoms by increasing blood flow to the heart muscle and reducing the heart's oxygen demand during physical exertion.
● Enhanced exercise tolerance: Patients with angina can engage in more physical activity with fewer chest pain episodes.
● Better overall cardiovascular health: By improving coronary blood flow, it helps reduce the frequency and severity of angina attacks.
4. Dual Effect: Blood Pressure and Angina Management
Felodipine丨CAS 72509-76-3 addresses both hypertension and angina, making it a suitable treatment option for patients with coexisting high blood pressure and coronary artery disease.
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Conclusion
A concise summary and suitability assessment for this product is available on request. Contact our team to discuss whether it fits your process and quality requirements.