Ethyl propionylacetate

Ethyl propionylacetate丨CAS 4949-44-4 is a β-keto ester, an important class of compounds in organic synthesis due to their high reactivity, particularly in nucleophilic addition, condensation, and alkylation reactions. This compound is used as a versatile intermediate in the pharmaceutical, flavor & fragrance, and fine chemical industries.

1. Pharmaceutical Intermediate

Ethyl propionylacetate丨CAS 4949-44-4 acts as a building block for synthesizing heterocycles such as pyridines, pyrimidines, and pyrazoles, which are common in drug discovery.

Used in the preparation of active pharmaceutical ingredients (APIs) including:

Antiviral compounds

Non-steroidal anti-inflammatory drugs (NSAIDs)

Anticonvulsants and antihypertensives

Enables carbon–carbon bond formation in enolate chemistry to create more complex molecules.

2. Agrochemical Synthesis

Intermediate for producing herbicides, fungicides, and insecticides.

Contributes to the synthesis of biologically active heterocyclic scaffolds relevant to crop protection.

3. Flavors and Fragrances

Occasionally used in the production of synthetic aromas due to its mild fruity odor.

Acts as a precursor for creating flavor enhancers or fragrance modifiers, especially in fruit and sweet profiles.

4. Research and Fine Chemicals

Widely used in academic and industrial research as a model compound in carbonyl and enolate chemistry.

Participates in Knoevenagel, Claisen, Michael, and aldol condensations, making it a key reagent for forming complex organic molecules.

1. Reactivity

As a β-keto ester, it has dual electrophilic centers (the ketone and ester), making it useful for selective and sequential transformations.

Easily undergoes deprotonation at the α-carbon, enabling alkylation, acylation, or condensation reactions.

2. Synthetic Versatility

Compatible with many common organic transformations.

Enables one-pot reactions and multi-step syntheses of heterocycles and fine chemicals.

3. Readily Available and Cost-Effective

Commercially accessible in high purity.

Offers a balance between chemical reactivity and stability for lab and industrial use.

4. Mild Handling Conditions

Liquid form is convenient for scaling reactions in both lab and plant environments.

Stable under standard storage and reaction conditions when protected from moisture and acids.

Ethyl propionylacetate丨CAS 4949-44-4 is a valuable β-keto ester intermediate used in the pharmaceutical, agrochemical, and flavor & fragrance industries. Its dual reactivity and compatibility with a wide range of organic reactions make it a key tool in heterocyclic chemistry, C–C bond formation, and medicinal compound synthesis. Easy to handle and cost-effective, it remains a staple in both research and industrial chemical synthesis.

Previous

Protoporphyrin IX Dimethyl Ester丨CAS 5522-66-7

Next

Disodium Adenosine 5-phosphate丨CAS 4578-31-8