CAS · 1761-61-1
Product Overview
5-Bromosalicylaldehyde is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | White to yellow crystals |
|---|---|
| Purity (HPLC) | 99% min |
| Melting point | 104–105 °C |
| Ash | 0.5% max |
| Moisture | 0.5% max |
Applications
5-Bromosalicylaldehyde is an important aromatic aldehyde widely used in pharmaceutical research, coordination chemistry, and organic synthesis. It serves as a key intermediate in the preparation of Schiff bases, heterocyclic compounds, and bioactive molecules through condensation reactions with amines, hydrazines, and other nucleophiles. In medicinal chemistry, it is applied in the synthesis of antimicrobial, anticancer, and anti-inflammatory agents, where the salicylaldehyde framework contributes to biological activity. In coordination and inorganic chemistry, 5-bromosalicylaldehyde is commonly used to prepare metal–Schiff base complexes that are studied for catalytic, magnetic, and biological properties. It is also utilized in agrochemical development, dye synthesis, and functional material research. The compound serves as a valuable precursor for further functionalization through halogen substitution and cross-coupling reactions.
Benefits
The benefits of 5-bromosalicylaldehyde arise from its dual functional groups, high reactivity, and synthetic versatility. The aldehyde group enables efficient condensation and cyclization reactions, while the phenolic hydroxyl group supports hydrogen bonding and metal coordination. The bromine substituent provides a reactive site for palladium-catalyzed coupling reactions, facilitating structural diversification and molecular modification. This combination of functional groups allows multiple reaction pathways in a single molecule, supporting efficient multi-step synthesis. The compound exhibits good stability under standard storage conditions and compatibility with common organic solvents and reagents, ensuring reproducible performance in laboratory and industrial research.
Conclusion
5-Bromosalicylaldehyde is a versatile and high-value intermediate for pharmaceutical synthesis, coordination chemistry, and advanced material research. Its aldehyde, phenolic, and halogen functionalities enable diverse chemical transformations and structural optimization. By supporting efficient Schiff base formation, cross-coupling reactions, and metal complex design, this compound continues to play a significant role in modern organic, inorganic, and medicinal chemistry applications.
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