CAS · 7318-00-5
Product Overview
Ethyl 3-aminocrotonate is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | Clear, transparent, colorless liquid or solid |
|---|---|
| Purity (GC) | 99.5% min |
| Ethyl acetoacetate (GC) | 0.15% max |
| Methyl 3-aminocrotonate (GC) | 0.03% max |
| Other single impurity (GC) | 0.3% max |
| Total impurity (GC) | 0.5% max |
Applications
Ethyl 3-aminocrotonate (CAS 7318-00-5) is a versatile intermediate in organic synthesis and pharmaceutical chemistry. It is widely used in the synthesis of heterocyclic compounds, including pyridines, pyrimidines, and other nitrogen-containing scaffolds that are common in drug discovery. In medicinal chemistry, it serves as a building block for the preparation of bioactive molecules such as antiviral, antibacterial, and anticancer agents. Additionally, ethyl 3-aminocrotonate is employed in the synthesis of fine chemicals, dyes, and agrochemicals, where its dual functional groups-a reactive amine and an α,β-unsaturated ester-enable diverse chemical transformations including condensation, Michael addition, and cyclization reactions.
Benefits
The benefits of ethyl 3-aminocrotonate arise from its bifunctional nature, combining an amino group with an α,β-unsaturated ester. This allows for high reactivity and selectivity in synthetic pathways, facilitating the formation of C–C and C–N bonds. The compound is chemically stable, soluble in common organic solvents, and compatible with various reaction conditions, making it suitable for multi-step synthesis. Its structure provides flexibility for derivatization, enabling the creation of a wide range of analogs and scaffolds for drug discovery and material development. These features make it a highly valuable intermediate in both laboratory and industrial synthesis.
Conclusion
Ethyl 3-aminocrotonate is a key intermediate in pharmaceutical and fine chemical synthesis, offering versatility and reactivity due to its amino and α,β-unsaturated ester functionality. Its ability to participate in diverse chemical transformations makes it essential for the synthesis of heterocycles, bioactive molecules, and specialty chemicals. By supporting efficient and selective reactions, it continues to play a crucial role in medicinal chemistry, organic synthesis, and advanced chemical development.
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