CAS · 1350653-23-4
Product Overview
1H-Pyrazolo3,4-bpyridine, 5-fluoro-3-iodo- is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance: | Yellow powder |
|---|---|
| Purity: | 98% min |
| Maximum single impurity: | 1% max |
| HPLC: | The principal peak in the chromatogram obtained with the test solution is similar in retention time to the principal peak in the chromatogram obtained with reference solution |
| Moisture: | 0.5% max |
| Residue on ignition: | 0.5% max |
Applications
1H-Pyrazolo[3,4-b]pyridine, 5-fluoro-3-iodo- is a valuable heterocyclic compound widely used as an intermediate in pharmaceutical and chemical research. Its dual halogen substitution (fluoro and iodo groups) makes it a versatile building block in the synthesis of bioactive molecules, particularly kinase inhibitors, antiviral agents, and anticancer drug candidates. The compound's pyrazolopyridine core is a privileged scaffold in medicinal chemistry, often incorporated into structures that modulate biological targets such as protein kinases, GPCRs, and enzymes. It is also utilized in organic synthesis for introducing fluorine and iodine functionalities into complex molecules via cross-coupling reactions such as Suzuki, Sonogashira, or Buchwald–Hartwig reactions.
Benefits
This compound offers unique synthetic flexibility due to the presence of both fluorine and iodine substituents. The iodo group enables efficient coupling reactions, while the fluorine atom enhances metabolic stability, lipophilicity, and binding affinity of derivatives in drug discovery. Its heteroaromatic structure provides strong electronic properties, making it a suitable precursor for developing compounds with improved pharmacokinetics and bioavailability. Additionally, it can serve as a key intermediate in creating analogs for SAR (structure–activity relationship) studies, supporting the development of novel therapeutic agents in oncology, neurology, and infectious diseases.
Conclusion
1H-Pyrazolo[3,4-b]pyridine, 5-fluoro-3-iodo- is an important fluorinated and iodinated heterocycle used in advanced pharmaceutical synthesis and medicinal chemistry research. Its multifunctional structure provides an excellent foundation for designing innovative bioactive compounds, making it a highly valuable intermediate for modern drug discovery and fine chemical development.
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