CAS · 29557-51-5
Product Overview
Dodecylphosphocholine is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance: | White Powder |
|---|---|
| Purity: | 99% min |
Applications
1. Membrane Protein Solubilization
One of the most commonly used detergents for solubilizing membrane proteins while preserving their native structure and function.
Its mild properties help maintain protein folding, allowing for further structural or functional studies.
2. NMR Spectroscopy of Proteins
DPC is frequently used in solution-state NMR of membrane proteins, such as G-protein coupled receptors (GPCRs), ion channels, and transporters.
It forms small, isotropic micelles, which are ideal for high-resolution NMR analyses.
3. Structural Biology and Crystallography
Employed in the reconstitution of proteins into membrane-mimetic environments, such as bicelles, micelles, or nanodiscs.
Facilitates crystallization trials and functional assays.
4. Model Membranes and Lipid Studies
Used in studies of lipid-protein interactions, membrane dynamics, and lipid bilayer properties.
Often included in liposome formulations or mixed micelles to mimic the cell membrane.
5. Drug Delivery and Formulations (experimental)
As a surfactant, DPC is explored in drug solubilization systems and as part of lipid-based delivery vehicles for poorly water-soluble compounds.
Benefits
✅ Zwitterionic Nature
Electrically neutral at physiological pH, minimizing nonspecific interactions with biomolecules.
Mimics natural phospholipid head groups, supporting biologically relevant protein environments.
✅ Low CMC and Small Micelle Size
Critical micelle concentration (CMC) around 1–2 mM, with micelles ~5 nm in diameter.
Suitable for NMR and EM imaging due to uniform micelle size and excellent protein compatibility.
✅ High Purity and Reproducibility
Available in ultrapure, research-grade forms, ideal for high-resolution structural analysis.
✅ Widely Studied and Validated
Extensively referenced in the literature, with known performance profiles across different experimental conditions.
Conclusion
Dodecylphosphocholine (CAS 29557-51-5) is a versatile, zwitterionic surfactant that plays a critical role in the solubilization, stabilization, and structural study of membrane proteins. Its compatibility with NMR, micelle formation, and native-like properties makes it an essential tool in modern biophysical and biochemical research.
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