CAS · 536-66-3
Product Overview
4-Isopropylbenzoic acid is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance: | Off white powder |
|---|---|
| Assay: | 98% min |
| Melting point: | 116-120℃ |
| Water: | 0.3% max |
| Residue on ignition: | 0.3% max |
Applications
1. Pharmaceutical Intermediate
Serves as a key building block for the synthesis of various active pharmaceutical ingredients (APIs) and drug candidates.
The carboxylic acid functional group allows for the formation of esters, amides, and other derivatives essential for medicinal chemistry.
The isopropyl substituent influences lipophilicity and steric properties, affecting drug-receptor interactions.
2. Agrochemical Synthesis
Used as an intermediate in the production of herbicides, insecticides, and fungicides.
The aromatic and alkyl-substituted framework supports bioactivity and selectivity against target organisms.
3. Organic Synthesis
Employed as a precursor for the preparation of substituted benzoic acids and aromatic compounds.
Useful in cross-coupling reactions, esterification, and amide formation.
Enables structural modification to tune physical and chemical properties of target molecules.
4. Materials Science
Can be used in the synthesis of specialty polymers and plasticizers, where the aromatic acid structure provides rigidity and thermal stability.
May serve as a precursor in the development of liquid crystals or dye intermediates.
Benefits
1. Versatile Functional Groups
The combination of a reactive carboxylic acid group and a hydrophobic isopropyl substituent provides versatility in chemical transformations.
Facilitates the design of molecules with tailored solubility and bioavailability profiles.
2. Influences Molecular Properties
The isopropyl group increases lipophilicity compared to benzoic acid, affecting permeability and interaction with biological membranes.
Para substitution pattern contributes to predictable steric and electronic effects.
3. Synthetic Accessibility
Commercially available and relatively easy to handle, making it convenient for research and industrial use.
Compatible with various synthetic methods and reaction conditions.
4. Stable and Easy to Store
Solid at room temperature with good stability under standard storage conditions.
Low volatility and ease of purification make it practical for scale-up synthesis.
Conclusion
4-Isopropylbenzoic acid (CAS 536-66-3) is a valuable aromatic carboxylic acid intermediate widely used in pharmaceutical, agrochemical, and materials chemistry. Its functional groups offer synthetic flexibility, allowing for the creation of diverse derivatives with tailored properties. The presence of the isopropyl group enhances molecular characteristics such as lipophilicity, making it a useful scaffold in drug development and specialty chemical manufacturing.
Previous
Next