DL-4-Chlorophenylalanine methyl ester hydrochloride
CAS 14173-40-1
CAS · 14173-40-1
Product Overview
DL-4-Chlorophenylalanine methyl ester hydrochloride is a high-purity biochemical-reagents supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | White powder |
|---|---|
| Purity (HPLC) | 98% min |
| Melting Point | 180°C min |
| Specific Rotation [α]₍20ᴰ₎ | 0° (C = 1 in MeOH) |
| Clarity of Solution | 0.3 g in 2 mL H₂O gives a clear solution |
| Water Content (K.F.) | 2.0% max |
| Loss on Drying | 2.0% (70°C, 2 h) |
| IR Spectrum | In accordance with the structure |
| Mass Spectrum | In accordance with the structure |
| NMR Spectrum | In accordance with the structure |
Applications
DL-4-Chlorophenylalanine methyl ester hydrochloride is mainly used as an intermediate in the synthesis of pharmaceuticals, peptide-related compounds, and fine chemicals. It serves as a building block in the preparation of amino acid derivatives, especially when constructing modified phenylalanine units for drug discovery or biochemical research. In peptide synthesis, it is used for incorporating chlorinated aromatic residues that adjust hydrophobicity, binding affinity, or metabolic behavior in peptide leads. The compound is also applied in the development of enzyme inhibitors, receptor-binding ligands, and bioactive molecules where the 4-chlorophenyl moiety plays a functional role. In research laboratories, it is often used as a substrate or reference compound in studies involving amino acid metabolism, chiral analysis, and structure–activity relationship investigations. Its ester form offers good reactivity and ease of incorporation into multi-step synthetic pathways.
Benefits
DL-4-Chlorophenylalanine methyl ester hydrochloride offers several advantages due to its structural versatility and predictable reactivity. The presence of both the ester group and the 4-chlorophenyl substituent allows chemists to efficiently introduce functional diversity into synthetic intermediates, supporting the development of drug candidates and specialized biochemical tools. Its hydrochloride salt form improves handling, solubility, and stability during storage, allowing for more controlled reactions and reduced degradation. The compound's compatibility with standard peptide-coupling reagents and protecting-group strategies enables streamlined synthesis and reliable yield outcomes. In research environments, its defined structure makes it useful for mechanistic studies, chemical modification work, and the generation of analog libraries for medicinal chemistry exploration.
Conclusion
DL-4-Chlorophenylalanine methyl ester hydrochloride is a valuable synthetic intermediate used in pharmaceutical development, peptide chemistry, and biochemical research. Its stability, structural functionality, and ease of incorporation into complex molecules make it a practical and effective tool for creating modified amino acid derivatives and exploring structure–activity relationships. These characteristics support its continued use across diverse scientific and industrial applications.
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