CAS · 3432-99-3
Product Overview
5,10-Methylene tetrahydro folic acid is a high-purity analytical-reagents supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | Off-white solid |
|---|---|
| Identification (1H-NMR) | NMR |
| Identification (13C-NMR) | NMR |
| Identification (MS) | MS |
| TGA (400°) | 10% max |
| Chemical purity (HPLC Area%) | 90% max |
Applications
5,10-Methylene tetrahydrofolic acid is primarily used in biochemical and pharmaceutical research due to its role as a coenzyme in folate metabolism. It participates in the synthesis of thymidylate from deoxyuridylate, a crucial step in DNA replication and repair. Because of this function, it is frequently used in studies related to cell proliferation, cancer biology, and antifolate drug mechanisms. In molecular biology and enzymology research, it is used to investigate enzyme systems such as thymidylate synthase and other folate-dependent enzymes. The compound also serves as a reference material in metabolic pathway studies and diagnostic research related to folate deficiency and metabolic disorders. In pharmaceutical development, it is important for studying mechanisms of antifolate drugs used in chemotherapy and antimicrobial therapies.
Benefits
One of the key benefits of 5,10-methylene tetrahydrofolic acid is its central role in one-carbon transfer reactions, which are essential for nucleotide biosynthesis and normal cellular metabolism. Its biological activity allows researchers to better understand metabolic pathways that regulate DNA synthesis and cellular growth. The compound provides valuable insight into disease mechanisms involving folate metabolism, including cancer and certain genetic metabolic disorders. In laboratory settings, it helps improve the accuracy of enzyme assays and metabolic studies. Additionally, its well-characterized biochemical behavior allows it to be used effectively in controlled experimental systems for drug discovery and metabolic research. Its role as a natural metabolic intermediate also makes it highly relevant for studies on nutritional biochemistry and vitamin metabolism.
Conclusion
5,10-Methylene tetrahydrofolic acid is an essential folate-derived cofactor that plays a critical role in DNA synthesis and cellular metabolism. Its importance in biochemical pathways, cancer research, and enzyme studies makes it a valuable compound in pharmaceutical and life science research. As scientific understanding of metabolic regulation and targeted therapies continues to grow, this compound remains a key tool in modern biochemical and biomedical research.
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