CAS · 32213-95-9
Product Overview
Dimethyl L-aspartate hydrochloride is a high-purity amino-acids supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | White crystalline powder |
|---|---|
| Purity | 98.5% min |
| Specific Rotation (20/D) | +14.5° - +14.9° (C=1, CH₃OH) |
| Non-animal origin | Conforms |
Applications
Dimethyl L-aspartate hydrochloride is primarily used as a building block in peptide synthesis, allowing the selective incorporation of aspartic acid residues without side reactions involving free carboxyl groups. It is widely applied in the production of small peptides, peptidomimetics, and pharmaceutical intermediates. In medicinal chemistry, it serves as a precursor for the synthesis of drugs, enzyme inhibitors, and chiral intermediates, where precise stereochemistry is critical. The compound is also used in organic synthesis to prepare functionalized derivatives of aspartic acid, including esters, amides, and heterocycles, as well as in research laboratories for studying amino acid chemistry, structure–activity relationships, and metabolic analogs.
Benefits
One of the key benefits of dimethyl L-aspartate hydrochloride is its protected form, which prevents unwanted side reactions during peptide coupling or multi-step synthesis. The hydrochloride salt improves water solubility and stability, facilitating accurate handling and formulation in laboratory and industrial processes. Its L-configuration preserves the natural stereochemistry, which is essential for maintaining biological activity in peptides and bioactive molecules. The methyl ester groups can be selectively hydrolyzed under mild conditions, providing flexibility for further functionalization. Additionally, the compound is compatible with a wide range of solvents and coupling reagents, allowing efficient synthesis of high-purity peptides and intermediates.
Conclusion
Dimethyl L-aspartate hydrochloride is a versatile amino acid derivative widely used in peptide synthesis, pharmaceutical intermediate production, and chemical research. Its protected ester form, stereochemical fidelity, and enhanced solubility make it a valuable building block for creating bioactive peptides, drug candidates, and functionalized organic molecules. As peptide therapeutics and chiral intermediates continue to grow in demand, this compound remains a critical reagent in modern organic and medicinal chemistry.
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