Di-tert-butyl[3,4,5,6-tetramethyl-2′,4′,6′-tris(propan-2-yl)-[1,1′-biphenyl]-2-yl]phosphane

Di-tert-butyl[3,4,5,6-tetramethyl-2′,4′,6′-tris(propan-2-yl)-[1,1′-biphenyl]-2-yl]phosphane is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.

This compound is a highly sterically hindered phosphine ligand, widely used in organometallic chemistry and homogeneous catalysis. It is employed as a key ligand in transition-metal-catalyzed reactions such as cross-coupling, hydrogenation, and C–H activation due to its ability to stabilize metal centers and influence reaction selectivity. The bulky substituents provide both electronic and steric control, enabling high regio- and stereoselectivity in complex organic transformations. It finds applications in pharmaceutical synthesis, fine chemical production, and materials chemistry where precision catalytic control is critical. Additionally, this phosphine ligand is used in the development of new catalytic systems and in academic research to study ligand effects on metal-mediated reaction mechanisms.

The key benefits of this ligand lie in its steric bulk and electron-donating characteristics, which enhance the stability of metal-ligand complexes and prevent unwanted side reactions. Its unique structure allows fine-tuning of catalytic activity, resulting in improved yields, selectivity, and reaction rates in organometallic processes. The ligand's robustness under diverse reaction conditions-including high temperature and oxidative environments-makes it suitable for demanding industrial and laboratory syntheses. Additionally, its high specificity reduces catalyst degradation and minimizes by-product formation, improving overall efficiency. The modularity of this phosphine also supports customization in designing ligands for new or challenging catalytic transformations.

Di-tert-butyl[3,4,5,6-tetramethyl-2',4',6'-tris(propan-2-yl)-[1,1'-biphenyl]-2-yl]phosphane is a highly effective bulky phosphine ligand widely used in homogeneous catalysis and organometallic chemistry. Its steric and electronic properties enhance metal complex stability, reaction selectivity, and overall efficiency, making it invaluable in pharmaceutical synthesis, fine chemical production, and catalytic research.

Previous

(R)-(+)-N-Boc-2-piperidinecarboxylic Acid丨CAS 28697-17-8

Next

L-Ornithine Acetate丨CAS 60259-81-6