CAS · 91832-40-5
Product Overview
Cefdinir is a high-purity a-api supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Grade: | CP2020 |
|---|---|
| Characteristics: | Faintly yellow to yellow crystalline powder, slight odour |
| Assay: | 94.0% min (on anhydrous) |
| Identification: | IR, HPLC Complies |
| Crystalline: | Complies |
| Specific Rotation: | -58° ~ -66° |
| Specific absorbance: | 570 ~ 610 |
| pH: | 2.5 ~ 4.5 |
| Water: | 2.0% max |
| Residue on ignition: | 0.2% max |
| Heavy metals: | 10 ppm max |
| Tetrahydrofuran: | 0.072% max |
| Methylene chloride: | 0.06% max |
| Triethylamine: | 0.032% max |
| Acetic acid: | 0.5% max |
| Ethanol: | 0.5% max |
| Impurity A: | 0.5% max |
| Impurity B: | 0.2% max |
| Impurity C: | 0.2% max |
| Impurity D: | 0.2% max |
| Impurity E: | 0.5% max |
| Impurity F: | 0.5% max |
| Impurity O: | 0.2% max |
| Impurity P: | 0.5% max |
| Impurity Q: | 0.5% max |
| Impurity R: | 0.5% max |
| Impurity S: | 0.5% max |
| Impurity T: | 0.5% max |
| Impurity U: | 0.5% max |
| Impurities G + H: | 0.7% max |
| Impurities I + J + K + L: | 0.7% max |
| Impurities M + N: | 0.7% max |
| Any Individual impurity: | 0.2% max |
| Total impurities: | 3.0% max |
| Total Microbial count: | 1000 CFU/g max |
| Moulds and yeasts: | 100 CFU/g max |
| Escherichia Coli: | ND |
Applications
1. Treatment of Respiratory Tract Infections
Cefdinir丨91832-40-5 is commonly prescribed for:
● Acute bacterial otitis media (middle ear infection)
● Pharyngitis/tonsillitis (caused by Streptococcus pyogenes)
● Sinusitis
● Acute exacerbations of chronic bronchitis
● Community-acquired pneumonia
It is particularly effective against common respiratory pathogens such as:
● Streptococcus pneumoniae
● Haemophilus influenzae
● Moraxella catarrhalis
2. Skin and Soft Tissue Infections
● Used to treat uncomplicated skin and skin structure infections (SSSIs), such as:
Cellulitis
Impetigo
Wound infections
● Active against Staphylococcus aureus and Streptococcus pyogenes, which are common causative agents.
3. Pediatric and Geriatric Use
● Frequently used in pediatric populations, especially for ear and throat infections, due to its pleasant taste in suspension form and favorable safety profile.
● Also suitable for elderly patients, as it has good oral bioavailability and can often eliminate the need for injectable antibiotics.
Benefits
1. Broad-Spectrum Activity
● Effective against a wide range of Gram-positive and Gram-negative organisms, including β-lactamase-producing strains.
● Good alternative to penicillin and older cephalosporins when resistance is suspected.
2. Oral Administration
● Available as oral capsules and powder for oral suspension, making it ideal for outpatient use and pediatric care.
● Eliminates the need for intravenous antibiotics in many cases.
3. Good Tolerability and Safety Profile
● Generally well-tolerated, with most adverse effects being mild and self-limited.
● Less likely to cause allergic reactions compared to penicillin.
4. Convenient Dosing
● Typically administered once or twice daily, depending on the indication.
● Short treatment duration (usually 5–10 days) increases patient compliance.
Pharmacokinetics and Mechanism of Action
● Mechanism: Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to cell lysis and death.
● Absorption: Oral bioavailability ~20-25%; absorption reduced by antacids or iron-containing products.
● Half-life: Approximately 1.7 hours; excreted mostly unchanged in the urine.
● No hepatic metabolism, making it safe for patients with liver impairment (but dose adjustment may be required in renal impairment).
Conclusion
Cefdinir丨91832-40-5 is a well-established third-generation cephalosporin antibiotic that offers broad-spectrum antibacterial coverage, excellent safety, and oral dosing convenience. It's a top choice for treating respiratory, ear, throat, skin, and soft tissue infections, especially in pediatrics and outpatient care. With its high efficacy and tolerability, cefdinir remains a reliable therapeutic option in the age of growing antibiotic resistance, provided it's used judiciously and appropriately.
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Conclusion
A concise summary and suitability assessment for this product is available on request. Contact our team to discuss whether it fits your process and quality requirements.