Bromopropylmagnesium

Bromopropylmagnesium is a high-purity grignard-reagent supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.

1. Alkylation Reactions

Used to introduce a 3-carbon propyl chain into molecules by reacting with electrophiles such as:

Carbonyl compounds (aldehydes, ketones, esters) to form secondary or tertiary alcohols

Epoxides (to form primary alcohols with an extended chain)

Acid chlorides and imines (to produce ketones or amines)

2. Synthesis of Functionalized Molecules

Serves as a key intermediate in the synthesis of:

Pharmaceuticals

Agrochemicals

Fragrance compounds

Specialty polymers

3. Preparation of Heterocycles

Used to build heterocyclic scaffolds through intramolecular cyclization after alkylation.

Enables the formation of five- or six-membered rings by introducing a reactive propyl handle.

4. Cross-Coupling Reactions (Kumada Coupling)

Acts as a nucleophilic coupling partner with aryl or vinyl halides in nickel- or palladium-catalyzed Kumada cross-coupling reactions, forming C–C bonds efficiently.

5. Organometallic Intermediate for Further Functionalization

The bromopropyl group allows for post-reaction modifications, such as displacement of the terminal bromide with nucleophiles (e.g., azide, thiol, amine) to create new functionalities.

1. Efficient Chain Elongation

Provides a convenient and reactive way to introduce a three-carbon alkyl chain onto various molecular backbones.

2. High Reactivity

As a Grignard reagent, it reacts readily with a wide range of electrophiles under mild conditions, facilitating fast and high-yielding transformations.

3. Synthetic Versatility

The terminal bromide in the propyl chain is useful for further transformations, making this reagent highly modular and adaptable for complex synthesis routes.

4. Compatibility with Modern Catalysis

Suitable for transition-metal-catalyzed reactions, such as Kumada–Corriu cross-coupling, expanding its utility beyond classical Grignard chemistry.

Bromopropylmagnesium (CAS 927-77-5) is a valuable Grignard reagent used for carbon–carbon bond formation, particularly in alkylation, ring formation, and transition-metal-catalyzed cross-coupling. It enables the installation of a 3-carbon side chain with a reactive bromide terminus, offering flexibility for further chemical modifications. Its high reactivity, synthetic versatility, and compatibility with modern organic synthesis techniques make it a useful tool in both academic research and industrial chemical production.

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