CAS · 79307-93-0
Product Overview
Azelastine hydrochloride is a high-purity a-api supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Description: | White to Off-White powder |
|---|---|
| Purity: | 99% min |
| Identification: | The retention time of the major peak in the chromatogram of sample corresponds to that in the chromatogram of standard preparation |
| Methanol: | 0.3% max |
| Alcohol: | 0.5% max |
| Acetone: | 0.5% max |
| Isopropyl alcohol: | 0.5% max |
| DCM: | 0.06% max |
| Single impurity: | 0.2% max |
| Total impurities: | 0.5% max |
| Loss on drying: | 0.5% max |
| Residue on ignition: | 0.5% max |
Applications
1. Antihistamine for Allergic Rhinitis
Azelastine hydrochloride is widely used as a topical nasal spray for treating:
Seasonal allergic rhinitis (SAR)
Perennial allergic rhinitis (PAR)
It provides rapid relief from symptoms such as:
Sneezing
Runny nose
Nasal itching
Nasal congestion
2. Ophthalmic Use
Formulated as eye drops for treating allergic conjunctivitis, reducing:
Eye itching
Redness
Swelling and tearing caused by allergens
3. Chronic Urticaria Treatment
Though less common, it may be used orally or topically to manage chronic idiopathic urticaria (hives) and other skin-related allergic reactions.
4. Non-Sedating Antihistamine
Unlike many first-generation antihistamines, Azelastine acts selectively on H1 receptors and crosses the blood-brain barrier minimally, reducing sedation.
5. Adjunctive Therapy in Asthma
Occasionally used off-label in conjunction with other asthma therapies for its mast cell-stabilizing and anti-inflammatory effects.
Benefits
🌬️ Fast and Localized Relief
When administered intranasally or ocularly, it works within minutes, offering targeted symptom relief directly at the site of allergic inflammation.
🧠 Minimal Sedation
Its second-generation antihistamine properties reduce CNS penetration, making it less likely to cause drowsiness than traditional antihistamines.
💊 Dual Action
Azelastine provides:
Antihistamine action (H1-receptor blockade)
Mast cell stabilization, reducing the release of histamine and inflammatory mediators
🧴 Multiple Delivery Forms
Available in nasal sprays, eye drops, and oral formulations, allowing flexibility depending on the nature and site of the allergic reaction.
📈 Proven Efficacy
Clinically proven to be effective in reducing allergy symptoms without significantly affecting daily activities or cognitive function.
🌿 Well-Tolerated
Has a favorable side-effect profile compared to systemic antihistamines, especially when used topically.
Conclusion
Azelastine hydrochloride (CAS 79307-93-0) is a highly effective, second-generation antihistamine used primarily to treat allergic rhinitis and allergic conjunctivitis. Its fast-acting, non-sedating, and dual-action properties make it a preferred choice in allergy management. By delivering targeted relief through nasal and ocular formulations, Azelastine offers both efficacy and convenience for patients suffering from seasonal and year-round allergies. Its use continues to expand as a reliable, well-tolerated therapy in both clinical and over-the-counter settings.
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