CAS · 5447-02-9
Product Overview
3,4-Dibenzyloxybenzaldehyde is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | Light Yellow to Yellow Powder |
|---|---|
| Purity | 98% min |
| Total Impurities | 2.0% max |
| Loss on drying | 0.5% max |
Applications
1. Organic Synthesis Intermediate
Serves as a precursor to 3,4-dihydroxyphenylethanol, achieving high yields through methods that avoid highly toxic reagents and minimize environmental impact.
Used in synthesizing 5,6-dihydroxyindole, a compound relevant in the production of melanin, dyes, fragrances, and pharmacological agents. Its benzyloxy groups protect the phenolic sites during multistep reactions, enabling higher yields and reduced by-products.
2. Pharmaceutical Intermediate
Plays a key role in the synthesis of droxidopa, a therapeutic agent for neurogenic orthostatic hypotension in Parkinson's disease and related disorders.
In the synthetic route, 3,4-dibenzyloxybenzaldehyde is obtained via protection of 3,4-dihydroxybenzaldehyde, followed by further transformations including condensation, acetylation, and deprotection to yield the active pharmaceutical ingredient.
The protection strategy allows for efficient reactions without degradation of sensitive phenolic hydroxyl groups.
3. Specialty Research & Synthesis
Widely used in research laboratories and industrial-scale synthesis as an intermediate for producing phenolic derivatives, bioactive molecules, and specialty chemicals.
Not intended for direct application in consumer products without further processing or modification.
Benefits
High Yield and Efficiency
Enables high-yield conversions for downstream compounds, supporting cost-effective manufacturing.
Protection of hydroxyl groups minimizes side reactions, improving purity and yield.
Synthetic Versatility
Applicable across multiple chemical pathways, making it suitable for fine chemical production, pharmaceutical synthesis, and advanced material research.
Cost and Environmental Efficiency
Avoids excessively toxic reagents and employs greener synthesis methods, reducing waste and lowering production costs.
Strategic Protection Group Functionality
Benzyloxy groups serve as effective protecting groups for phenolic hydroxyls, allowing controlled multistep synthesis while preserving functional group integrity.
Conclusion
3,4-Dibenzyloxybenzaldehyde is a valuable intermediate in both organic and pharmaceutical synthesis. Its stability, ease of handling, and strategic use as a protected form of 3,4-dihydroxybenzaldehyde make it indispensable for high-yield production of compounds such as droxidopa, 3,4-dihydroxyphenylethanol, and 5,6-dihydroxyindole. Its combination of high yield potential, environmental compatibility, and functional versatility ensures its continued use in both laboratory and industrial chemical processes.
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