CAS · 1806766-70-0
Product Overview
6-(Difluoromethyl)-5-methylpyridin-3-amine is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | Yellow solid |
|---|---|
| Purity | 95% min |
Applications
6-(Difluoromethyl)-5-methylpyridin-3-amine (CAS 1806766-70-0) is a fluorinated heterocyclic compound widely used as an intermediate in pharmaceutical and agrochemical synthesis. Its pyridine core, substituted with difluoromethyl, methyl, and amino groups, makes it a versatile building block for the design of bioactive molecules, including kinase inhibitors, enzyme modulators, and receptor-targeted therapeutics. In medicinal chemistry, it is employed to introduce fluorinated motifs that enhance metabolic stability, binding affinity, and lipophilicity in drug candidates. In agrochemical research, it serves as a precursor for herbicides, fungicides, and insecticides, providing improved potency and environmental stability. Additionally, it is used in fine chemical research to develop fluorinated heterocyclic scaffolds for structure–activity relationship (SAR) studies.
Benefits
The benefits of 6-(difluoromethyl)-5-methylpyridin-3-amine stem from its multifunctional reactivity and fluorinated structure. The amino group enables selective derivatization through acylation, alkylation, or condensation reactions, while the difluoromethyl group enhances metabolic stability, modulates electronic properties, and improves membrane permeability in bioactive compounds. The pyridine ring provides a rigid, planar scaffold suitable for binding in biological targets, and the methyl substitution contributes steric and lipophilic effects that can optimize pharmacokinetics. Together, these features make it a valuable intermediate for designing molecules with enhanced potency, selectivity, and chemical stability.
Conclusion
In summary, 6-(difluoromethyl)-5-methylpyridin-3-amine is an important intermediate in pharmaceutical and agrochemical research. Its applications include the synthesis of kinase inhibitors, receptor ligands, and crop-protection agents, while its benefits lie in fluorine-induced metabolic stability, versatile functionalization, and scaffold rigidity. As demand grows for fluorinated heterocycles in drug discovery and agrochemicals, this compound remains a critical building block for developing potent and stable bioactive molecules.
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