CAS · 888721-83-3
Product Overview
6-bromo-3H,4H-pyrrolo2,1-f1,2,4triazin-4-one is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance: | White Solid |
|---|---|
| 1H NMR Spectrum: | Conforms |
| HPLC Spectrum: | Conforms to reference |
| Assay (HPLC, w/w %): | 99% min |
| Purity (HPLC, w/w %): | 99% min |
| Identified Impurity 1 (HPLC, w/w %): | 0.5% max |
| Identified Impurity 2 (HPLC, w/w %): | 0.5% max |
| Identified Impurity 3 (HPLC, w/w %): | 0.5% max |
| Identified Impurity 4 (HPLC, w/w %): | 0.5% max |
| Largest unspecified impurity (Area %) (RRT=1.17): | 0.5% max |
| Identified Impurity 5 (HPLC, w/w %): | 0.5% max |
| Identified Impurity 6 (HPLC, w/w %): | 0.5% max |
| Identified Impurity 7 (HPLC, w/w %): | 0.5% max |
| Residual Solvent (GC): | 0.5% max |
| Residual Solvent (GC): | 0.5% max |
| Residual Solvent (GC): | 0.5% max |
| Residual Solvent (GC): | 0.5% max |
| Residual Solvent (GC): | 0.5% max |
| Residual Solvent (GC): | 0.5% max |
| Residual Solvent (HPLC): | 0.1% max |
| Residual Solvent (GC, ppm): | 500 max (MF) |
| Water (KF) (%): | 0.5% max |
| Residue on Ignition (%): | 0.5% max |
Applications
6-Bromo-3H,4H-pyrrolo[2,1-f][1,2,4]triazin-4-one is a valuable heterocyclic compound widely used as a key intermediate in pharmaceutical and chemical research. It serves as a core structural unit in the synthesis of nucleoside analogs, kinase inhibitors, and antiviral agents, particularly in the development of potential treatments for cancer, viral infections, and inflammatory diseases. The bromine substituent on the pyrrolo-triazine scaffold provides a reactive site for further chemical modifications such as cross-coupling and substitution reactions, allowing chemists to design and produce diverse derivatives with targeted biological activities. In medicinal chemistry, it is an essential building block in the synthesis of triazine-based heterocycles, which are known for their potent pharmacological properties. Furthermore, its unique molecular framework makes it a useful compound for structure–activity relationship (SAR) studies and drug discovery programs focused on purine-mimicking molecules.
Benefits
The advantages of 6-Bromo-3H,4H-pyrrolo[2,1-f][1,2,4]triazin-4-one lie in its chemical stability, synthetic versatility, and biological relevance. It offers an efficient route to functionalized pyrrolo-triazine compounds, enabling high-yield coupling reactions that streamline pharmaceutical synthesis processes. The compound's robust aromatic system contributes to favorable electronic characteristics, enhancing its compatibility in complex organic transformations. From a research perspective, its brominated structure facilitates selective substitution, allowing precise control over chemical derivatization and optimization of pharmacokinetic properties in drug candidates. Its adaptability also reduces time and cost in lead compound development. Owing to these properties, it has become an indispensable reagent for laboratories focused on new chemical entity (NCE) discovery and medicinal chemistry innovation.
Conclusion
6-Bromo-3H,4H-pyrrolo[2,1-f][1,2,4]triazin-4-one is a high-value intermediate recognized for its significant contribution to modern drug design and synthetic chemistry. Its reactivity, structural versatility, and role in creating biologically active molecules make it a preferred choice among researchers developing next-generation pharmaceuticals. By enabling efficient molecular modification and facilitating the synthesis of promising therapeutic scaffolds, this compound continues to support scientific advancement and innovation across chemical and pharmaceutical research.
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