CAS · 199174-24-8
Product Overview
(S)-1-Boc-3-hydroxymethylpyrrolidine is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | Light yellow to yellow liquid |
|---|---|
| HNMR | Confirms to structure |
| Purity (GC) | 97% Min |
| Ee | 98% Min |
| Water (KF) | 0.5% Max |
| Suggested Storage Conditions | Kept in room temperature (10-30 ℃), nitrogen-filled preservation |
Applications
(S)-1-Boc-3-hydroxymethylpyrrolidine is primarily used as a chiral building block in organic synthesis and pharmaceutical research. It serves as an intermediate in the preparation of bioactive molecules, chiral ligands, and heterocyclic compounds. The Boc-protected amine group provides selective protection during multi-step synthesis, while the hydroxymethyl functionality allows further chemical transformations, including oxidation, substitution, and coupling reactions. This compound is widely employed in the synthesis of antiviral, anticancer, and central nervous system (CNS)-active agents, as well as in the development of novel catalysts and chiral auxiliaries for asymmetric synthesis.
Benefits
The benefits of (S)-1-Boc-3-hydroxymethylpyrrolidine include its enantiomeric purity, chemical stability, and versatility in synthetic applications. The S-configuration provides stereochemical control in downstream reactions, which is critical for producing biologically active compounds with defined activity. The Boc protecting group ensures selective reactivity of the amine during multi-step syntheses, and the hydroxymethyl group allows for a wide range of functionalizations. Its stability, ease of handling, and compatibility with common solvents and reagents make it a reliable intermediate for complex organic synthesis and pharmaceutical development.
Conclusion
(S)-1-Boc-3-hydroxymethylpyrrolidine is a valuable chiral intermediate used in the synthesis of bioactive molecules, chiral ligands, and heterocyclic compounds. Its stereochemical purity, protected amine, and reactive hydroxymethyl group provide versatility and control in multi-step organic syntheses. These properties make it an essential building block in pharmaceutical research and asymmetric synthesis applications.
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