CAS · 1953-54-4
Product Overview
5-Hydroxyindole is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance: | Red to brown crystalline powder |
|---|---|
| Purity (HPLC): | 98% min |
| Melting Point: | 106℃ to 108℃ |
| Loss on drying: | 0.5% max |
| Residue on ignition: | 0.1% max |
| 1H-NMR: | Conforms to structure |
| IR: | Conforms to reference |
Applications
5-Hydroxyindole is a key heterocyclic compound widely used in pharmaceutical and biochemical research. It serves as an important intermediate in the synthesis of serotonin derivatives, tryptophan analogs, and other bioactive molecules. This compound is commonly employed in medicinal chemistry for designing neuroactive agents, antidepressants, and enzyme inhibitors. In addition, 5-hydroxyindole is used in the preparation of dyes, pigments, and fluorescent probes due to its electron-rich indole core, which facilitates conjugation and optical activity. Researchers also utilize it as a building block in the synthesis of natural product analogs and indole-based heterocycles for drug discovery and chemical biology studies.
Benefits
5-Hydroxyindole offers several advantages stemming from its reactive hydroxyl and indole moieties. The hydroxyl group allows selective functionalization through etherification, esterification, or alkylation reactions, while the indole ring participates in electrophilic substitution and cyclization processes, enabling the construction of complex heterocyclic structures. Its structural similarity to tryptophan and serotonin makes it valuable for studying neurotransmitter pathways and receptor interactions. Furthermore, its chemical stability and compatibility with a variety of organic reactions make it a reliable intermediate for laboratory and industrial-scale synthesis.
Conclusion
5-Hydroxyindole is a versatile heterocyclic intermediate with significant applications in medicinal chemistry, chemical biology, and material science. Its reactive hydroxyl and indole functionalities enable the synthesis of neuroactive compounds, dyes, and natural product analogs. With its stability, reactivity, and structural relevance to biologically important molecules, 5-hydroxyindole continues to play a critical role in drug discovery, research, and functional material development.
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