CAS · 475207-59-1
Product Overview
Sorafenib tosylate is a high-purity a-api supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | White or yellow powder |
|---|---|
| Purity | 99.0% min. |
| Identification | HPLC |
| Residue on ignition | 0.5% max. |
| Loss on Drying | 1.0% max. |
| Total impurity | 1.0% max. |
| Single impurity | 0.5% max. |
Applications
Sorafenib tosylate is primarily used in the pharmaceutical industry as a multikinase inhibitor for the treatment of various cancers, including advanced renal cell carcinoma, hepatocellular carcinoma, and differentiated thyroid carcinoma. It functions by inhibiting tumor cell proliferation and angiogenesis through targeting multiple kinases involved in the RAF/MEK/ERK pathway and receptor tyrosine kinases such as VEGFR and PDGFR. In research, Sorafenib tosylate is utilized to study kinase signaling pathways, cancer cell growth, angiogenesis mechanisms, and the development of novel anticancer therapeutics. It is also employed in drug development for preclinical evaluation of combination therapies and resistance mechanisms in oncology.
Benefits
Sorafenib tosylate offers several advantages in therapeutic and research contexts. Its ability to target multiple kinases simultaneously allows effective suppression of tumor growth and angiogenesis, making it a potent treatment option for various cancers. The tosylate form improves solubility and stability, facilitating formulation into oral dosage forms. Its well-characterized pharmacokinetics and reproducible bioactivity support reliable clinical outcomes and preclinical studies. Additionally, Sorafenib tosylate serves as a valuable tool in research for exploring kinase inhibition, combination therapy strategies, and mechanisms of drug resistance, contributing to the advancement of targeted cancer therapies.
Conclusion
Sorafenib tosylate is a multikinase inhibitor with applications in cancer treatment, pharmacological research, and drug development. Its targeted activity, solubility, and established efficacy make it valuable in both therapeutic and preclinical research settings. Overall, Sorafenib tosylate supports effective tumor suppression, exploration of kinase pathways, and development of advanced anticancer strategies.
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