(4R,6S)-6-(Chloromethyl)-2,2-dimethyl-1,3-dioxane-4-acetic Acid 1,1-Dimethylethyl Ester
CAS 154026-94-5
CAS · 154026-94-5
Product Overview
(4R,6S)-6-(Chloromethyl)-2,2-dimethyl-1,3-dioxane-4-acetic Acid 1,1-Dimethylethyl Ester is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | Light yellow to brown black oily liquid |
|---|---|
| Purity (GC) | 90% min |
| Water | 0.5% max |
Applications
In terms of applications, this compound is widely used as a versatile intermediate in the synthesis of complex molecules, particularly in the preparation of active pharmaceutical ingredients and bioactive compounds. Its chiral 1,3-dioxane ring system, combined with the chloromethyl functional group and ester moiety, provides multiple reactive sites for chemical modifications. This allows it to serve as a building block in the synthesis of stereochemically defined compounds, including antiviral, antibacterial, and anticancer agents. It is also utilized in asymmetric synthesis, where maintaining precise stereochemistry is critical for the biological activity of the final product. In research and development, it is valuable for constructing libraries of chiral compounds for drug discovery programs and studying structure-activity relationships.
Benefits
The benefits of this compound stem from its structural versatility and stereochemical specificity. The presence of the (4R,6S)-configuration ensures predictable stereochemical outcomes in subsequent reactions, which is essential for developing biologically active molecules with high potency and minimal side effects. Its chloromethyl group allows for selective substitution reactions, while the ester functionality provides a handle for further transformations such as hydrolysis or coupling reactions. These properties make it highly useful for producing enantiomerically pure compounds, improving reaction efficiency, and supporting precise synthetic strategies. The compound's stability and well-defined stereochemistry also enhance reproducibility in both laboratory and industrial-scale synthesis.
Conclusion
In conclusion, (4R,6S)-6-(Chloromethyl)-2,2-dimethyl-1,3-dioxane-4-acetic acid 1,1-dimethylethyl ester is a valuable chiral intermediate in chemical and pharmaceutical synthesis. Its applications in constructing stereochemically defined molecules, combined with the benefits of reactivity, versatility, and enantiomeric purity, make it an important tool for drug development and advanced chemical research. It continues to support innovation in the creation of bioactive compounds and precision synthetic methodologies.
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