CAS · 417721-36-9
Product Overview
4-chloro-7-methoxyquinoline-6-carboxamide is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | Off-white to brown powder |
|---|---|
| Purity | 98.0% min |
| Identification | The retention time of the major peak of the Sample solution corresponds to that of the Standard solution |
| Loss on drying | 1.0% max |
| Residue on ignition | 0.5% max |
| Individual impurities | 1.0% max |
| Total impurities | 2.0% max |
Applications
4-Chloro-7-methoxyquinoline-6-carboxamide (CAS 417721-36-9) is a heterocyclic intermediate primarily used in pharmaceutical and medicinal chemistry. Its quinoline core, combined with chloro, methoxy, and carboxamide substituents, provides multiple reactive sites for chemical modification, making it a valuable building block in the synthesis of antiviral, antibacterial, and anticancer agents. It is commonly employed in structure–activity relationship (SAR) studies to optimize potency, selectivity, and pharmacokinetic properties of drug candidates. The compound is also used in the preparation of fused heterocycles and other quinoline derivatives with potential therapeutic applications.
Benefits
The benefits of 4-chloro-7-methoxyquinoline-6-carboxamide lie in its chemical versatility and stability. The chloro substituent enables selective halogenation or cross-coupling reactions, while the methoxy group and carboxamide provide additional sites for derivatization and hydrogen bonding interactions. This multifunctionality allows chemists to efficiently generate diverse analogs for drug discovery programs. The compound is chemically stable, soluble in common organic solvents, and compatible with a variety of reaction conditions, supporting reproducible and scalable synthesis. Its quinoline scaffold imparts rigidity and planarity, which can enhance binding affinity and selectivity in bioactive molecules.
Conclusion
4-Chloro-7-methoxyquinoline-6-carboxamide is a valuable heterocyclic intermediate in pharmaceutical research and drug development. Its multifunctional quinoline scaffold enables selective transformations and facilitates the synthesis of diverse bioactive derivatives. By combining chemical stability, reactivity, and structural versatility, it continues to serve as a critical building block in the design and optimization of therapeutic agents.
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