CAS · 106-38-7
Product Overview
4-Bromotoluene is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | Colorless transparent liquid or white crystal |
|---|---|
| Purity (GC) | 99.9% min |
| o-Tolyl bromide (GC) | 0.1% max |
| 3-Bromo-1-methyl-benzene (GC) | 0.05% max |
| Other impurity (GC) | 0.05% max |
| Water (KF) | 0.1% max |
Applications
4-Bromotoluene (CAS 106-38-7) is an essential halogenated aromatic compound widely used as an intermediate in organic synthesis, pharmaceutical development, agrochemicals, and materials science. Featuring both a bromine atom and a methyl group attached to a benzene ring in a para configuration, it serves as a versatile substrate for cross-coupling reactions such as Suzuki, Heck, and Stille reactions. These transformations enable the formation of diverse aromatic compounds and biaryl systems used in active pharmaceutical ingredients (APIs), liquid crystals, and fine chemicals. In the chemical industry, 4-bromotoluene is also a precursor for synthesizing 4-cyanotoluene, 4-methylphenylboronic acid, and 4-methylbenzaldehyde. Its structure makes it a convenient starting material for the design of functionalized aromatic compounds and heterocyclic frameworks.
Benefits
The benefits of 4-bromotoluene include its stability, high reactivity toward palladium-catalyzed coupling, and structural simplicity, which make it a valuable and reliable building block. Its para substitution pattern provides predictable reactivity and easy access to symmetric derivatives with desirable electronic properties. The compound's bromine atom serves as an excellent leaving group, allowing for efficient substitution or coupling with various nucleophiles and organometallic reagents. Furthermore, its tolyl group contributes to favorable solubility and steric characteristics in final products, enhancing performance in both laboratory-scale synthesis and industrial manufacturing. Its wide commercial availability and cost-effectiveness further add to its appeal as a foundational intermediate.
Conclusion
4-Bromotoluene is a key aromatic intermediate with broad utility in pharmaceuticals, fine chemicals, and advanced materials synthesis. Its combination of a reactive bromine substituent and a methyl group enables efficient derivatization and construction of complex molecular architectures. As a cornerstone reagent for modern synthetic chemistry, 4-bromotoluene continues to facilitate the development of high-performance compounds across chemical and material sciences.
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