CAS · 118754-53-3
Product Overview
4-Bromo-3,5-dichlorobenzotrifluoride is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance: | Colorless to light yellow liquid |
|---|---|
| Purity (GC): | 98% min |
| Impurities: | 0.5% max |
| Water: | 0.5% max |
| Boiling point: | 238.9 ±35℃ at 760 mmHg |
Applications
4-Bromo-3,5-dichlorobenzotrifluoride is an important halogenated aromatic compound widely used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and specialty materials. Its electron-withdrawing trifluoromethyl group, along with bromine and chlorine substituents, makes it highly valuable for cross-coupling reactions such as Suzuki, Heck, and Stille couplings, enabling the creation of complex aromatic systems. In pharmaceutical research, it serves as a key building block for the development of active pharmaceutical ingredients (APIs) and fluorinated drug candidates, where halogenation enhances lipophilicity, metabolic stability, and biological activity. In agrochemical manufacturing, it is used to prepare herbicides, fungicides, and insecticides with improved environmental persistence and efficacy. Additionally, it is employed in the production of specialty chemicals, functional monomers, and advanced materials where thermal and chemical stability are required.
Benefits
The benefits of 4-bromo-3,5-dichlorobenzotrifluoride lie in its chemical reactivity, structural stability, and versatility. The combination of bromine, chlorine, and trifluoromethyl groups provides multiple reactive sites for selective functionalization, enabling efficient synthesis of substituted aromatic compounds. The trifluoromethyl group enhances chemical resistance, hydrophobicity, and thermal stability in the resulting derivatives, making them suitable for high-performance applications. Its compatibility with a range of catalytic systems and reaction conditions allows for reproducible and scalable processes in both laboratory and industrial settings. Furthermore, the compound's stability under storage and processing conditions ensures long shelf life and consistent quality. These properties make it an indispensable intermediate for chemists developing new fluorinated compounds with tailored physical, chemical, and biological profiles.
Conclusion
4-Bromo-3,5-dichlorobenzotrifluoride (CAS 118754-53-3) is a valuable multifunctional intermediate for pharmaceutical, agrochemical, and advanced material synthesis. Its halogen-rich structure and trifluoromethyl functionality enable high reactivity, selectivity, and stability, supporting the efficient production of complex and durable chemical products. By combining chemical robustness with synthetic flexibility, this compound plays a key role in modern organic synthesis and high-performance material development.
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