4-Bromo-3-fluoroiodobenzene

4-Bromo-3-fluoroiodobenzene is a high-purity fluorine supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.

4-Bromo-3-fluoroiodobenzene is widely used as a versatile intermediate in organic synthesis, particularly in the pharmaceutical and agrochemical industries. It serves as a building block for the preparation of fluorinated aromatic compounds, which are important in drug development due to their enhanced metabolic stability and bioactivity. This compound is also utilized in cross-coupling reactions such as Suzuki, Sonogashira, and Buchwald-Hartwig couplings to create complex molecules including heterocycles, active pharmaceutical ingredients (APIs), and specialty chemicals. Its dual halogen functionality allows selective functionalization, enabling multi-step synthetic routes.

The presence of both bromine and iodine atoms on the aromatic ring provides high reactivity and selectivity in various palladium-catalyzed cross-coupling reactions. This dual halogenation enables sequential or selective substitutions, improving synthetic flexibility and efficiency. The fluorine substituent contributes to enhanced chemical and metabolic stability in final products, which is valuable in drug design. Additionally, its stability under typical laboratory conditions facilitates handling and storage, streamlining synthetic workflows.

4-Bromo-3-fluoroiodobenzene is a critical intermediate that supports advanced synthetic strategies in pharmaceutical and agrochemical research. Its combination of halogen atoms and fluorine enables precise molecular modifications, enhancing the development of bioactive compounds and specialty chemicals with improved properties.

Previous

Perfluorobutyl Iodide丨CAS 423-39-2

Next

2,3,5,6-Tetrafluorophenol丨CAS 769-39-1