CAS · 5162-44-7
Product Overview
4-Bromo-1-butene is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | Colorless to pale yellow liquid |
|---|---|
| Assay | 98% min |
| Boiling point | 98 to 100 °C |
Applications
Organic Synthesis Intermediate
Functions as a versatile building block in synthetic chemistry, useful for constructing more complex molecules through alkylation, substitution, or addition reactions.
Specialized Derivative Synthesis
Used to prepare derivatives like 4-(3-butenyloxy)benzoic acid and larger natural product frameworks such as largazole.
Ring-Closing Reactions
Key component in double-alkylation of lactams followed by ring-closing metathesis, aiding in the formation of complex bicyclic structures like gymnodimine analogs.
Diene Hydrazide Formation
Employed in the synthesis of diene-hydrazides, serving as a precursor in subsequent heterocycle or enehydrazide formation.
Benefits
Dual Reactivity
Possesses both an alkene and a bromide functional group, facilitating diverse reaction pathways including nucleophilic substitution and olefin-related transformations.
Physical Handling Convenience
A clear, colorless liquid with a boiling point around 98–100 °C, readily soluble in organic solvents, and stable under standard laboratory conditions.
High Purity & Consistency
Available at high (>97%) purity, providing reliability and reproducibility in synthetic applications.
Synthetic Efficiency
Enables streamlined synthesis of challenging structures due to its reactive handles, reducing steps and increasing yield when constructing cyclic and acyclic frameworks.
Conclusion
4-Bromo-1-butene is a potent and adaptable intermediate-ideal for constructing complex molecular architectures in both medicinal chemistry and fine chemical synthesis. Its combination of reactivity, ease of handling, and availability at high purity makes it a go-to reagent for sophisticated organic transformations, including ring formations and specialized derivative synthesis.
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