CAS · 103-90-2
Product Overview
4-Acetamidophenol is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Grade: | BP2018/USP42 |
|---|---|
| Appearance: | White or almost white crystalline powder |
| Assay: | 99.0–101.0% (calculated on dry basis) |
| Solubility: | Sparingly soluble in water, freely soluble in alcohol, very slightly soluble in methylene chloride |
| Identification: | |
| Melting Point: | 168–172.0℃ |
| IR: | Consistent with the spectrum obtained with Paracetamol CRS |
| Related substances: | |
| Impurity J (chloroacetanilide): | 10 ppm max |
| Impurity K (4-aminophenol): | 50 ppm max |
| Impurity F (4-nitrophenol): | 0.05% max |
| Any other impurity: | 0.05% max |
| Total of other impurities: | 0.1% max |
| Loss on drying: | 0.5% max |
| Residue on ignition: | 0.1% max |
| Residual Solvents: | |
| Acetic acid: | 0.5% max |
| Microbial limits: | |
| Total aerobic bacteria: | 2000 cfu/g max |
| Combined molds and yeasts: | 200 cfu/g max |
| Escherichia coli: | Absence |
Applications
1. Pharmaceutical Industry
Widely used as an analgesic and antipyretic
Reduces pain (mild to moderate) and fever.
One of the most commonly used over-the-counter (OTC) medications globally.
Used as a standalone drug or in combination formulations with:
Caffeine
Codeine
Diphenhydramine
Phenylephrine
Available in various dosage forms:
Tablets, capsules, suspensions, syrups, suppositories, and intravenous solutions.
2. Intermediate in Drug Synthesis
Serves as a starting material for the synthesis of:
Other analgesics and antipyretics
Some dye intermediates and pesticide derivatives
3. Biochemical Research
Used as a reference compound for studying:
Hepatotoxicity mechanisms (due to its liver metabolism)
Oxidative stress and metabolic pathways in liver cells
Benefits
✔️ Highly Effective
Demonstrates effective fever reduction and pain relief for conditions such as:
Headache
Toothache
Muscle aches
Menstrual cramps
Cold and flu symptoms
✔️ Low Gastrointestinal Irritation
Unlike NSAIDs (e.g., ibuprofen, aspirin), paracetamol:
Has minimal effect on gastric lining
Does not inhibit COX-1 significantly, reducing GI ulcer risk
✔️ Safe at Recommended Doses
Safe for children and adults when used as directed
Often recommended for patients with ulcers or those who cannot tolerate NSAIDs
✔️ Versatile Formulation Options
Can be formulated into liquid, solid, or injectable forms
Allows rapid onset of action in suitable delivery formats (e.g., IV paracetamol)
Conclusion
4-Acetamidophenol (Paracetamol/Acetaminophen) is a cornerstone in modern medicine for its analgesic and antipyretic properties. It is globally trusted for pain and fever relief with a strong safety profile when used responsibly. In addition to its therapeutic uses, it plays a role in chemical synthesis, research, and formulation science, making it one of the most essential small molecules in both pharmaceutical and laboratory settings.
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