CAS · 14401-72-0
Product Overview
3,5-Dichloroacetophenone is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance: | Yellow liquid |
|---|---|
| Purity (GC): | 98% min |
| Total impurity: | 2.0% max |
Applications
Pharmaceutical Intermediate
Used in the synthesis of APIs and intermediates, particularly in compounds requiring electron-withdrawing groups on aromatic ketones.
Organic Synthesis
Acts as a key building block for constructing more complex aromatic or heterocyclic systems.
Agrochemical R&D
Serves as a precursor in the design of herbicides, fungicides, and plant growth regulators due to its halogenated aromatic structure.
Fragrance and Dye Intermediates
Can be functionalized further into specialty chemicals used in fragrance formulations or azo dyes.
Benefits
Enhanced Reactivity for Derivatization
The ketone functional group combined with chlorine substituents enhances electrophilic reactivity, making it suitable for condensation and substitution reactions.
Stability and Shelf Life
The molecule is relatively stable under ambient conditions, allowing for long-term storage and handling.
Electron-Withdrawing Substituents
Chlorine atoms at 3,5-positions increase the electron deficiency of the ring, useful for tuning the electronic properties in target molecules.
Versatile Precursor
Easily modified to introduce additional functional groups such as amines, hydrazones, oximes, or heterocycles.
Used in SAR Studies
Valuable in medicinal chemistry for structure-activity relationship (SAR) explorations due to its symmetrical substitution pattern.
Conclusion
3,5-Dichloroacetophenone (CAS 14401-72-0) is a strategically useful intermediate in the synthesis of pharmaceuticals, agrochemicals, and specialty organic compounds. Its halogenated structure and reactive ketone group offer chemists a reliable foundation for further functionalization, enabling efficient design of biologically active or functionally diverse molecules. Its reactivity, stability, and electronic profile make it a versatile tool in modern organic synthesis.
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