tert-butyl N-3-(aminomethyl)oxetan-3-ylcarbamate

tert-butyl N-3-(aminomethyl)oxetan-3-ylcarbamate is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.

tert-Butyl N-3-(aminomethyl)oxetan-3-ylcarbamate is a multifunctional synthetic intermediate widely used in medicinal chemistry and organic synthesis. It contains both an oxetane ring and a protected amino group, making it an ideal building block for the synthesis of drug-like molecules and complex heterocycles. The oxetane moiety serves as a compact, polar, and metabolically stable bioisostere for gem-dimethyl, cyclobutane, or carbonyl groups, frequently employed to improve physicochemical and pharmacokinetic properties in drug candidates. This compound is commonly used in the design of pharmaceuticals targeting CNS disorders, oncology, and antiviral pathways, as it enhances water solubility, lipophilicity balance, and metabolic stability. The tert-butyl carbamate (Boc) group provides a convenient protecting function for the amine, allowing selective deprotection under mild conditions during multi-step synthesis. Additionally, it is valuable in combinatorial chemistry, fragment-based drug discovery, and peptidomimetic development.

The benefits of tert-butyl N-3-(aminomethyl)oxetan-3-ylcarbamate arise from its structural versatility, stability, and functional compatibility in synthetic design. The oxetane ring imparts favorable molecular properties such as reduced lipophilicity, improved aqueous solubility, and enhanced three-dimensionality, leading to better drug-likeness and pharmacokinetic profiles. The Boc-protected amino group allows orthogonal chemistry, facilitating incorporation into various synthetic routes without unwanted side reactions. Its stable crystalline form and ease of handling improve reproducibility and storage life. Furthermore, incorporation of oxetane-containing motifs can modulate metabolic pathways, reducing clearance rates and improving bioavailability in drug candidates. This compound's ability to enhance molecular rigidity while maintaining reactivity makes it an essential tool for medicinal chemists seeking to fine-tune lead compound structures and optimize ADME characteristics.

tert-Butyl N-3-(aminomethyl)oxetan-3-ylcarbamate (CAS 1802048-96-9) is a valuable synthetic intermediate featuring the advantageous oxetane scaffold and a protected amino group. Its dual functionality supports complex molecular construction in pharmaceutical research, particularly for improving solubility, stability, and pharmacokinetic balance in drug design. By combining chemical stability, structural precision, and synthetic flexibility, it serves as a key reagent in modern medicinal chemistry and innovative compound development.

Previous

N-Hexylcarbazole丨CAS 4041-21-8

Next

N,N-Dimethylmethyleneiminium Iodide丨CAS 33797-51-2