CAS · 1692-25-7
Product Overview
3-Pyridylboronic acid is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | Off-white powder |
|---|---|
| Purity (HPLC) | 99.0% min |
| NMR | Conforms |
Applications
3-Pyridylboronic acid is widely used in cross-coupling reactions, particularly Suzuki–Miyaura coupling, for forming carbon–carbon bonds between heteroaromatic systems. It is a key building block in the synthesis of pharmaceuticals, agrochemicals, and functional organic materials, especially for compounds containing pyridine motifs. In medicinal chemistry, it is employed to construct bioactive molecules such as kinase inhibitors, antiviral agents, and CNS-active compounds. The boronic acid group also enables its use in the preparation of boron-containing ligands, sensors, and coordination complexes. Additionally, it is applied in materials science for developing electronic materials, fluorescent probes, and metal–organic frameworks (MOFs), as well as in research laboratories for studying coupling mechanisms and heterocyclic chemistry.
Benefits
The main benefits of 3-pyridylboronic acid include its high reactivity in palladium-catalyzed cross-coupling reactions, allowing efficient formation of complex molecular architectures under relatively mild conditions. The pyridine ring provides additional coordination capability, enabling interactions with metal catalysts and enhancing reaction versatility. Its dual functionality supports a wide range of transformations, including coupling, ester formation, and coordination chemistry. The compound is generally stable and can be handled under standard laboratory conditions, while its compatibility with various solvents and reagents facilitates multi-step synthesis. Additionally, it enables the introduction of heteroaromatic functionality into target molecules, which is highly valuable in drug discovery and materials development.
Conclusion
3-Pyridylboronic acid is a versatile heterocyclic building block widely used in cross-coupling reactions, pharmaceutical synthesis, and materials science. Its combination of a reactive boronic acid group and a functional pyridine ring makes it an essential intermediate for constructing complex, high-value molecules. As demand for heteroaromatic compounds and advanced materials continues to grow, this compound remains a key reagent in modern organic and medicinal chemistry.
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