CAS · 498-60-2
Product Overview
3-Furaldehyde丨CAS 498-60-2, is an organic compound with the molecular formula C5H4O2. It is one of the isomeric forms of furfural, distinguished by the position of the aldehyde group on the furan ring. Although not as commonly used as its isomer 2-furaldehyde (furfural), 3-furaldehyde has notable applications in organic synthesis, materials science, and chemical manufacturing.
Product Specifications
| Appearance | Colorless to pale yellow transparent liquid |
|---|---|
| Assay (GC) | 98% min |
| Water | 0.3% max |
Applications
A. Intermediate in Organic Synthesis
3-Furaldehyde is widely used as a building block in organic chemistry for the synthesis of:
Pharmaceutical intermediates
Agrochemicals
Specialty fine chemicals
Aromatic compounds and heterocycles
Due to the electrophilic nature of the aldehyde group and the electron-rich furan ring, it is suitable for nucleophilic addition reactions, condensations, and cyclization processes.
B. Pharmaceutical Industry
3-Furaldehyde has applications in the synthesis of active pharmaceutical ingredients (APIs) and their intermediates. It serves as a precursor for:
Antibacterial agents
Antifungal compounds
Potential anticancer scaffolds (by incorporating into furan-based heterocycles)
3-Furaldehyde丨CAS 498-60-2 also plays a role in drug discovery and medicinal chemistry, especially in the synthesis of heterocyclic frameworks.
C. Agrochemical Development
Used as a precursor for pesticides, herbicides, and plant growth regulators.
Incorporated into biologically active furan derivatives, which may exhibit insecticidal or fungicidal properties.
D. Polymer and Material Science
Used as a monomer or co-monomer in the development of furan-based polymers and resins.
Helps in improving the thermal and chemical stability of materials.
Potential use in bio-based polyesters and polyimides for sustainable materials.
E. Flavor and Fragrance Industry
Though less prominent than furfural, 3-furaldehyde may be used in trace amounts in fragrance chemistry for its slightly sweet, nutty aroma.
Can act as a starting material for the synthesis of flavor enhancers or aroma compounds.
F. Analytical and Research Uses
Employed as a reference standard in chromatographic analysis.
Studied for its photochemical and electrophilic behavior in academic and industrial research.
Benefits
A. High Reactivity
The aldehyde group at the 3-position allows for unique reactivity compared to its 2-isomer, providing different substitution and reaction pathways in synthetic chemistry.
B. Structural Versatility
The furan ring offers opportunities for diverse functionalization, making it suitable for synthesizing a variety of heterocyclic compounds.
C. Sustainability Potential
Furan derivatives, including 3-furaldehyde, can be derived from biomass-based carbohydrates, aligning with green chemistry principles.
Potential to be part of renewable chemical platforms for biorefineries.
Conclusion
3-Furaldehyde丨CAS 498-60-2 is a valuable chemical intermediate with broad utility in pharmaceuticals, agrochemicals, polymer science, and fine chemical synthesis. Though less commercially dominant than 2-furaldehyde, it offers unique reactivity and structural opportunities in chemical transformations. Its potential for sustainable production from biomass adds to its relevance in green and renewable chemistry initiatives. With appropriate handling and risk management, 3-furaldehyde is an effective tool in modern chemical manufacturing and research.
Previous
Hexafluorosilicic Acid丨CAS 16961-83-4
Next