CAS · 113-98-4
Product Overview
Penicillin G potassium is a high-purity veterinary-medicine supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Property | Specification |
|---|---|
| Appearance | A white or almost white crystalline powder |
| Assay (on dried basis) | 96% (1534 u/mg) min |
| HPLC | The retention time of the principal peak of the test solution should conform with that of the standard solution, as obtained in the Assay |
| IR | The IR spectrum obtained with the substance to be examined should conform with the reference spectrum or that obtained with the reference substance |
| pH | 5.0 - 7.5 |
| Appearance of Solution | It should be clear; if opalescent, not more opalescent than Reference Suspension I. It should be colorless; if color develops, it should be ≤ Reference Suspension II |
| Transmittance (400 nm) | 90% min |
| Water | 1% max |
Applications
1. Treatment of Bacterial Infections
Penicillin G potassium丨CAS 113-98-4 is administered intravenously (IV) or intramuscularly (IM) for:
● Streptococcal infections: Such as pharyngitis, cellulitis, and toxic shock syndrome.
● Pneumococcal infections: Including pneumonia and meningitis (if susceptible).
● Meningococcal meningitis: Especially in early or confirmed cases caused by Neisseria meningitidis.
● Syphilis: First-line treatment for all stages of syphilis caused by Treponema pallidum.
● Anthrax: As part of a multidrug regimen.
● Diphtheria and actinomycosis: Caused by susceptible organisms.
● Endocarditis: Caused by Streptococcus viridans or Enterococcus faecalis (in combination with aminoglycosides).
2. Veterinary Medicine
Used to treat bacterial infections in livestock and domestic animals, including:
● Respiratory infections
● Mastitis in dairy cattle
● Wound infections
● Septicemia
Its rapid onset of action is especially valuable in veterinary emergencies.
3. Surgical Prophylaxis
In select cases, especially with patients at risk of rheumatic heart disease, penicillin G potassium may be used perioperatively to prevent bacterial endocarditis.
Benefits
1. Broad Efficacy Against Gram-Positive Bacteria
● Highly effective against pathogens such as:
Streptococcus pyogenes
Streptococcus pneumoniae
Listeria monocytogenes
Clostridium perfringens
2. Rapid Onset of Action
● Water-soluble potassium salt ensures quick therapeutic levels in bloodstream.
● Ideal for acute infections requiring immediate intervention.
3. Low Toxicity and Well-Established Safety Profile
● Has been in use for decades with well-understood pharmacodynamics and minimal systemic toxicity when used appropriately.
● Suitable for pregnant women and children under medical supervision.
4. Bactericidal Action
● Unlike bacteriostatic agents, penicillin G potassium kills bacteria rather than just inhibiting their growth, providing rapid resolution of infections.
5. Cost-Effective
● Generic formulations are widely available, making it an economical option for treating susceptible infections in both human and animal healthcare.
Conclusion
Penicillin G potassium丨CAS 113-98-4 remains a cornerstone of antimicrobial therapy, particularly for severe systemic infections caused by susceptible Gram-positive organisms. Its rapid onset, low toxicity, and cost-effectiveness make it a preferred treatment option in both human and veterinary medicine. Despite the emergence of resistance, it retains high clinical value when used judiciously, often as part of targeted or combination therapy.
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