CAS · 407-20-5
Product Overview
3-Bromo-5-fluoropyridine is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | White low melting point solid |
|---|---|
| Purity (GC) | 98% min |
| Water content | 0.5% max |
Applications
1. Pharmaceutical Intermediate
Used as a building block in the synthesis of pharmaceutical compounds.
The halogen substituents (Br and F) provide sites for selective functionalization via cross-coupling reactions (e.g., Suzuki, Heck, or Buchwald-Hartwig coupling).
Enables the construction of heterocyclic drugs with improved pharmacokinetic properties.
2. Agrochemical Synthesis
Serves as an intermediate in the manufacture of pesticides, herbicides, and fungicides.
The halogenated pyridine scaffold is common in agrochemicals due to its biological activity.
3. Material Science
Used in the design of functional materials such as organic semiconductors, fluorescent probes, or ligands for metal complexes.
The fluorine atom can enhance thermal stability and lipophilicity, valuable for material performance.
4. Chemical Research
A useful substrate in medicinal chemistry and heterocyclic compound synthesis.
Provides a platform for studying structure-activity relationships (SAR) and halogen effects on biological activity.
Benefits
✅ Selective Reactivity
The bromine atom is a versatile leaving group for cross-coupling reactions, allowing precise chemical modification.
Fluorine imparts electronic effects and enhances metabolic stability in bioactive molecules.
✅ Enhanced Biological Activity
Halogenated pyridines often show improved binding affinity, bioavailability, and enzyme resistance.
✅ Stability
The presence of fluorine improves chemical and metabolic stability, which is valuable in both pharmaceuticals and agrochemicals.
✅ Synthetic Versatility
Enables the synthesis of a wide variety of derivatives for diverse applications.
Conclusion
3-Bromo-5-fluoropyridine (CAS 407-20-5) is a valuable intermediate widely used in pharmaceutical, agrochemical, and material science research. Its combination of bromine and fluorine substituents offers synthetic flexibility, enhanced stability, and potential to improve biological activity in target molecules, making it an important building block for developing novel compounds.
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