CAS · 114214-49-2
Product Overview
3-Boc-6-oxa-3-aza-bicyclo3.1.0hexane is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance: | Colourless or light yellow oil liquid |
|---|---|
| Purity (GC): | 96% min |
| Identification: | 1H NMR |
Applications
1. Pharmaceutical and Medicinal Chemistry
A. Intermediate in Drug Synthesis
● 3-Boc-6-oxa-3-aza-bicyclo[3.1.0]hexane is used as an intermediate in drug synthesis, particularly in the development of piperazine-based or nitrogen-containing heterocyclic compounds.
● The Boc group is typically used in the protection of amine groups, which are often key functional sites in bioactive compounds, such as antidepressants, analgesics, and antimicrobials.
B. Ligand Design and Molecular Recognition
● The structure of this compound, with its heteroatom-containing bicyclic framework, makes it a valuable ligand in the design of molecular recognition systems.
● It may be used in the development of receptor agonists or antagonists by incorporating it into larger molecules that interact with specific biological targets, such as GPCRs or ion channels.
2. Synthesis of Complex Organic Molecules
A. Building Block for Complex Natural Products
● The bicyclic structure of 3-Boc-6-oxa-3-aza-bicyclo3.1.0hexane丨CAS 114214-49-2 is an important building block for the synthesis of more complex organic molecules, particularly those with heterocyclic motifs.
● It can be used to construct polyketides, alkaloids, and other natural product analogs, which are often used in the synthesis of therapeutic agents.
B. Ring-Closing Reactions
● This compound can be involved in ring-closing reactions, such as ring-closing metathesis or nucleophilic substitution, to form larger, more intricate structures for pharmaceuticals or other bioactive molecules.
3. Synthesis of Bicyclic Amines
A. Bicyclic Amine Derivatives
● The nitrogen and oxygen atoms in the bicyclic structure make this compound a valuable precursor for the synthesis of bicyclic amines, which are important structural motifs in pharmaceuticals and biologically active molecules.
● Such bicyclic systems are commonly found in neurotransmitter receptor modulators, antiviral agents, and antidepressant compounds.
B. Customizable Functionalization
● After deprotecting the Boc group, the resulting amine group can undergo further functionalization, leading to the generation of a variety of derivatives. This makes it a flexible starting material for synthetic chemists working with amine chemistry.
4. Research and Development of Chemical Reactions
A. Studying Reaction Mechanisms
● 3-Boc-6-oxa-3-aza-bicyclo[3.1.0]hexane can be used in research settings to study the reaction mechanisms of heterocyclic ring formation and the behavior of Boc-protected amines in synthetic transformations.
● It can also serve as a model compound for exploring stereoselective synthesis and functional group interconversion.
5. Materials Science
A. Polymeric and Supramolecular Applications
● The compound's structure can be adapted to develop polymeric materials or supramolecular systems with specific properties, such as selective binding or solubility control.
● Research may explore its ability to integrate into polymeric matrices, such as controlled-release drug delivery systems.
Benefits
√ Protective Group Utility
● The Boc group allows for selective protection of amines, which makes the compound valuable in synthetic pathways where the amine is a reactive site, preventing unwanted reactions.
√ Heterocyclic Versatility
● The bicyclic structure, with both oxygen and nitrogen atoms, makes this compound a versatile intermediate in the synthesis of complex organic molecules, particularly those with potential biological activity.
√ High Synthetic Flexibility
● After deprotection of the Boc group, it is possible to modify the amine group in various ways, making this compound a highly adaptable starting material for custom molecular design.
√ Targeted Drug Design
● Its heterocyclic framework is a promising structure for designing targeted therapeutics, including neurotransmitter receptor or enzyme inhibitors, making it valuable in pharmaceutical development.
√ Important in Medicinal Chemistry
● Utilized as a synthetic intermediate for preparing complex, biologically active compounds, particularly those with amine functional groups.
Conclusion
3-Boc-6-oxa-3-aza-bicyclo3.1.0hexane丨CAS 114214-49-2 is a highly versatile compound in organic synthesis, especially within the pharmaceutical and biotechnology sectors. Its bicyclic structure containing both nitrogen and oxygen atoms is particularly useful in the synthesis of complex heterocyclic compounds and bicyclic amines, which are key building blocks in drug discovery and development. The Boc-protecting group adds to its synthetic flexibility by allowing selective protection of functional groups, enhancing its utility in pharmaceutical research and advanced chemical synthesis.
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Conclusion
A concise summary and suitability assessment for this product is available on request. Contact our team to discuss whether it fits your process and quality requirements.