CAS · 37595-74-7
Product Overview
N,N-Bis(trifluoromethylsulfonyl)aniline is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | White to off white crystals |
|---|---|
| Purity | 99% min |
| NH₂C₆H₅ | 0.3% max |
| C₆H₅NH(CF₃SO₂) | 0.5% max |
| H₂O | 0.2% max |
Applications
N,N-Bis(trifluoromethylsulfonyl)aniline is primarily used as a strong electron-withdrawing reagent and intermediate in organic synthesis and pharmaceutical chemistry. It is employed in the preparation of sulfonamide derivatives, fluorinated heterocycles, and specialty chemicals where the trifluoromethylsulfonyl group enhances chemical stability, lipophilicity, and biological activity. The compound is also used in the development of catalysts, reagents for electrophilic substitution reactions, and in medicinal chemistry for synthesizing bioactive molecules that require fluorinated functional groups. Its structural properties make it suitable for research applications involving advanced synthetic transformations and functionalized aromatic compounds.
Benefits
The benefits of N,N-Bis(trifluoromethylsulfonyl)aniline include its strong electron-withdrawing ability, chemical stability, and versatility in synthetic reactions. The trifluoromethylsulfonyl groups enhance reactivity in electrophilic aromatic substitution, facilitate selective derivatization, and improve solubility in organic solvents. Its stability under standard laboratory conditions ensures reproducible results in multi-step syntheses. The compound's unique combination of fluorinated sulfonyl groups and aniline functionality allows the design of molecules with tailored electronic, steric, and biological properties, making it valuable for both pharmaceutical and materials chemistry.
Conclusion
N,N-Bis(trifluoromethylsulfonyl)aniline is a versatile intermediate and reagent used in organic synthesis, pharmaceuticals, and specialty chemical research. Its electron-withdrawing trifluoromethylsulfonyl groups, stability, and synthetic versatility make it an important building block for creating fluorinated bioactive molecules and functionalized aromatic compounds. These properties support efficient and controlled chemical transformations in both research and industrial applications.
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